Comorbidity effects on cocaine dependence treatment and examination of reciprocal relationships between abstinence and depression.
Comorbidity effects on cocaine dependence treatment and examination of reciprocal relationships between abstinence and depression.
复制标题
合并症对可卡因依赖治疗的影响以及戒断和抑郁之间相互关系的检查。
DOI：
10.1037/a0037960
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发表时间：
2015
影响因子：
5.9
通讯作者：
Schumacher,JosephE
中科院分区：
文献类型：
--
作者：
Milby,JesseB;Conti,Kimberly;Wallace,Dennis;Mennemeyer,Stephen;Mrug,Sylvie;Schumacher,JosephE
我们检查共病障碍的患病率，其对禁欲的影响，抑郁症状的禁欲和禁欲对抑郁症状的影响。MethodA随机对照试验的数据从治疗可卡因依赖的结果。它比较了禁欲应急住房和工作应急管理加行为日治疗。无论最初的试验组分配如何，对无其他轴I疾病（n= 87）和1种或多种其他轴I疾病（n= 113）的受试者组进行禁欲比较。抑郁症状的变化，测量贝克抑郁量表，分析作为一个功能的4个队列的增加连续戒酒周。一个自回归交叉滞后路径模型研究抑郁症和abstinence.ResultsMost普遍的额外障碍之间的相互关系是抑郁症，其次是焦虑症。其他疾病并没有显着影响禁欲。更多禁欲的人群与较低的抑郁症状呈线性相关。交叉滞后模型显示，更长时间的禁欲预示着6个月时抑郁症状的减少。然而，抑郁症状并不能预测禁欲的变化。结论我们的研究增加了其他研究的成果，这些研究发现了针对药物滥用、社交焦虑症和创伤后应激障碍等特定问题的有效治疗方法，可能具有减轻抑郁症的副作用。此外，我们发现抑郁症不会干扰可卡因依赖的有效药物滥用治疗。这可能是第一次正式分析比较可卡因戒断预测未来抑郁症状与抑郁症状预测未来可卡因戒断的能力。（PsycInfo数据库记录（c）2020阿帕，保留所有权利）
ObjectiveWe examined comorbid disorders’ prevalence, their impact on abstinence, and the impact of depressive symptoms on abstinence and of abstinence on depressive symptoms.MethodA randomized controlled trial’s data on outcomes from treating cocaine dependence were used. It compared abstinence-contingent housing and work to contingency management plus behavioral day treatment. Regardless of original trial arm assignment, groups of participants with no additional Axis I disorders (n= 87) and 1 or more additional Axis I disorders (n= 113) were compared for abstinence. Changes in depression symptoms, measured by the Beck Depression Inventory, were analyzed as a function of 4 cohorts of increased consecutive weeks abstinent. An autoregressive cross-lagged path model examined reciprocal relationships between depression and abstinence.ResultsMost prevalent additional disorders were depressive disorders, followed by anxiety disorders. Additional disorders did not significantly affect abstinence. Cohorts with more abstinence were linearly related to lower depression symptoms. The cross-lagged model showed that longer abstinence predicted decreases in depressive symptoms at 6 months. However, depressive symptoms did not predict changes in abstinence.ConclusionsOur study adds to others that have found an effective treatment targeted at specific problems such as substance abuse, social anxiety disorder, and posttraumatic stress disorder that may have the side benefit of reducing depression. Additionally, we find that depression does not interfere with effective substance abuse treatment for cocaine dependency. This may be the 1st formal analysis comparing the ability of cocaine abstinence to predict future depressive symptoms versus depressive symptoms to predict future cocaine abstinence.(PsycInfo Database Record (c) 2020 APA, all rights reserved)