New photodynamic therapy protocol to treat AIDS-related Kaposi's sarcoma
New photodynamic therapy protocol to treat AIDS-related Kaposi's sarcoma
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DOI：
10.1089/pho.2006.24.528
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发表时间：
2006-08-01
影响因子：
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通讯作者：
Baptista, Mauricio S.
中科院分区：
文献类型：
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作者：
Tardivo, Joao P.;Del Giglio, Auro;Baptista, Mauricio S.
目的：本研究的目的是评估吩噻嗪化合物（亚甲蓝和甲苯胺蓝）光动力疗法（PDT）和非相干光源（RL50）激发治疗艾滋病相关卡波西肉瘤（Sk-AIDS）的效果。背景资料：Sk-AIDS是一种在艾滋病患者中反复发作的恶性疾病。基于激光的 PDT 方案已用于治疗 Sk-AIDS，并取得了相对成功的效果。方法：对一名化疗失败的多发病灶患者进行多次PDT治疗，并对患者进行密切评估。 PDT 方案包括将吩噻嗪化合物混合物注射到病变部位并以 18 J/cm(2) 施加 RL50。结果：观察到完全缓解，美容效果极佳。该结果根据已知的 PDT 作用机制进行了讨论，并与其他 PDT 方案进行了比较。结论：这种基于吩噻嗪化合物和 RL50 的廉价 PDT 方案可有效治疗 Sk-AIDS。
Objective: The aim of this study was to evaluate the efficiency of photodynamic therapy (PDT) with phenotiazinium compounds (methylene blue and toluidine blue) and excitation by a non-coherent light source (RL50) to treat AIDS-related Kaposi's sarcoma (Sk-AIDS). Background Data: Sk-AIDS is a malignant disease that is recurrent in AIDS patients. Laser-based PDT protocols have been applied to treat Sk-AIDS with relative success. Methods: A single patient with multiple lesions who had undergone chemotherapy without success was treated with several applications of PDT, and the patient was closely evaluated. The PDT protocol consisted of injecting a mixture of phenotiazinium compounds into the lesions and applying RL50 at 18 J/cm(2). Results: Complete remission with excellent cosmetic result was observed. This result was discussed in terms of the known mechanisms of PDT action and compared with other PDT protocols. Conclusion: This inexpensive PDT protocol, which is based on phenothiazinium compounds and RL50, is efficient to treat Sk-AIDS.