Toenail zinc level and gastric cancer risk in Cali, Colombia
Toenail zinc level and gastric cancer risk in Cali, Colombia
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DOI：
10.1007/s00432-007-0266-1
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发表时间：
2008-02-01
影响因子：
3.6
通讯作者：
Nakano, Atsuhiro
中科院分区：
文献类型：
--
作者：
Campos, Francia Ivonne;Koriyama, Chihaya;Nakano, Atsuhiro
目的探讨胃癌（GC）风险与趾甲中锌水平的关系，我们在2000年至2002年期间在卡利进行了一项以医院为基础的病例对照研究，方法从卡利三家医院新诊断的156名胃癌患者和从非胃癌患者中选择的287名对照者中获得趾甲剪片和包括饮食习惯在内的生活方式信息。与胃癌患者在同一家医院住院的癌症患者。结果趾甲锌含量与胃癌发病风险呈负相关（P趋势= 0.039）。当我们分别检查当前和以前的吸烟者和非吸烟者的这种关联时，只有当前吸烟者显示出显著的负相关（趋势P = 0.035）。组织学特异性分析显示，当我们将胃癌病例限制在卵巢型及其匹配对照组时，这种负相关性更强（趋势P < 0.001）。这种关联也被观察到在位于胃的上三分之二的癌（P趋势= 0.004），但不是在胃的下三分之一的癌（P趋势= 0.727）。然而，这种关联仅限于吸烟者、胃内型GC和胃上三分之二的肿瘤。进一步的研究似乎可以证实我们的发现。
Purpose To examine the associations between gastric cancer (GC) risk and the zinc levels in toenail clippings, we conducted a hospital-based case-control study during the period from 2000 to 2002 in Cali, Colombia.Methods Toenail clippings and information on lifestyles including dietary habits were obtained from 156 GC patients newly diagnosed in three hospitals in Cali and 287 controls selected from non-cancer patients who were hospitalized in the same hospitals as GC patients. Zinc concentrations in toenail clippings were examined using inductively coupled plasma mass spectrometry.Results An inverse association was observed between toenail zinc level and GC risk (P for trend = 0.039). When we examined this association separately for current and former smokers and non-smokers, only current-smokers showed a significant inverse association (P for trend = 0.035). Histology specific analysis revealed that this inverse association was stronger when we limited GC cases with intestinal-type and their matched controls (P for trend < 0.001). This association was also observed in the carcinomas located in the upper two-thirds of the stomach (P for trend = 0.004) but not in carcinomas in the lower-third of the stomach (P for trend = 0.727).Conclusions There was an inverse association between toenail zinc level and GC risk. However, the association was limited to smokers, intestinal-type GC, and tumors in the upper two-thirds of the stomach. Further studies seem warranted to confirm our findings.