A NEW T-CELL RECEPTOR GENE LOCATED WITHIN THE ALPHA-LOCUS AND EXPRESSED EARLY IN T-CELL DIFFERENTIATION
A NEW T-CELL RECEPTOR GENE LOCATED WITHIN THE ALPHA-LOCUS AND EXPRESSED EARLY IN T-CELL DIFFERENTIATION
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DOI：
10.1038/327677a0
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发表时间：
1987-06-25
期刊：
影响因子：
64.8
通讯作者：
DAVIS, MM
中科院分区：
文献类型：
--
作者：
CHIEN, YH;IWASHIMA, M;DAVIS, MM
一个新的T细胞受体基因位于JαCα编码区的5'端。它在这个位置的位置表明一个新的机制，在个体发育过程中的一个T细胞受体多肽的表达调节到另一个。该位点的重排发生在胸腺分化的早期，其RNA表达与胸腺亚群中γ链的表达平行，使其成为最近描述的T细胞受体δ链的可能候选者。
A new T-cell receptor gene lies just 5' to the JαCαcoding regions. Its placement in this location suggests a novel mechanism for the regulation of expression of one T-cell receptor polypeptide to another during ontogeny. Rearrangement of this locus occurs very early in thymic differentiation and its RNA expression parallels that of the γ-chain in thymic subpopulations, making this a possible candidate for the recently described δ-chain of the T-cell receptor.