On a Chemoenzymatic Desymmetrization–Ring Expansion Strategy towards Functionalized N-Heterocycles
On a Chemoenzymatic Desymmetrization–Ring Expansion Strategy towards Functionalized N-Heterocycles
复制标题
功能化 N-杂环的化学酶去对称化扩环策略
作者：
D. Thiel;J. Deska
Abstract The direct combination of the desymmetrization of N-heterocyclic meso-diols using lipase from Mucor miehei as biocatalyst and subsequent ring expansion of the optically active products by activation of the remaining hydroxy group gives rise to functionalized nonsymmetrical piperidines in a highly enantio- and diastereoselective manner.
