Peripheral nerve injury: A review and approach to tissue engineered constructs
Peripheral nerve injury: A review and approach to tissue engineered constructs
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DOI：
10.1002/ar.1120
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发表时间：
2001-08-01
影响因子：
--
通讯作者：
Evans, GRD
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文献类型：
--
作者：
Evans, GRD
每年有11，000名美国人受到瘫痪的影响，这是一种毁灭性的伤害，每年的相关费用为70亿美元（美国瘫痪协会，1997年）。目前，对于中枢神经系统（CNS）的损伤没有有效的治疗方法，并且急性脊髓损伤对治疗具有极大的抗性。与脊髓损伤相比，周围神经损伤更为常见。1995年，进行了超过50，000例外周神经修复手术。（国家卫生统计中心基于疾病分类，第9次修订，以下类别的临床修改：ICD-9 CM代码：04.3，04.5，04.6，04.7）。然而，这些数据可能低估了神经损伤的数量，因为并非所有的手术或创伤性病变都可以修复。此外，腹腔内手术可能会增加因肿瘤切除术对自主神经系统造成的神经损伤的数量。例如，评估根治性阴茎海绵体切除术后阳萎结局的研究表明，503名先前有效的男性中有212名（42%）在部分或完全切除一条或两条海绵体神经时发生阳萎。当神经保持完整时，该阳痿率降低至24%（Quinlan等人，J. Urol. 1991;145：380-383; J. Urol. 1991; 145：998-1002）。Anat Rec 263：396- 404，2001。(C)2001年威利-利斯。Inc.
Eleven thousand Americans each year are affected by paralysis, a devastating injury that possesses associated annual costs of $7 billion (American Paralysis Association, 1997). Currently, there is no effective treatment for damage to the central nervous system (CNS), and acute spinal cord injury has been extraordinarily resistant to treatment. Compared to spinal cord injury, damage to peripheral nerves is considerably more common. In 1995, there were in excess of 50,000 peripheral nerve repair procedures performed. (National Center for Health Statistics based on Classification of Diseases, 9th Revision, Clinical Modification for the following categories: ICD-9 CM Code: 04.3, 04.5, 04.6, 04.7). These data, however, probably underestimate the number of nerve injuries appreciated, as not all surgical or traumatic lesions can be repaired. Further, intraabodominal procedures may add to the number of neurologic injuries by damage to the autonomic system through tumor resection. For example, studies assessing the outcome of impotency following radical prostatectomy demonstrated 212 of 503 previously potent men (42%) suffered impotency when partial or complete resection of one or both cavernosal nerve(s). This impotency rate decreased to 24% when the nerves were left intact (Quinlan et al., J. Urol. 1991;145:380-383; J. Urol. 1991; 145:998-1002). Anat Rec 263:396-404,2001. (C) 2001 Wiley-Liss. Inc.