Evidence of distinct amino acid and bile salt receptors in the olfactory system of the zebrafish, Danio rerio.
Evidence of distinct amino acid and bile salt receptors in the olfactory system of the zebrafish, Danio rerio.
复制标题
斑马鱼嗅觉系统中存在独特氨基酸和胆汁盐受体的证据。
DOI：
10.1016/s0006-8993(97)00454-x
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发表时间：
1997
期刊：
影响因子：
2.9
通讯作者：
Derbidge,DS
中科院分区：
文献类型：
--
作者：
Michel,WC;Derbidge,DS
利用嗅觉电图记录技术对斑马鱼（Daniorerio）氨基酸和胆盐气味物质的分子受体进行了部分研究。测试的14种气味剂中的每一种都与部分独立的气味剂受体相互作用。基于共享的适应模式，聚类分析确定了两组非常不同的气味。第一组包括8种氨基酸，具有碱性、酸性和中性氨基酸的亚组。第二组包括6种胆汁盐，亚组为非结合型、牛磺酸结合型和甘氨酸结合型胆汁盐。氨基酸和胆盐气味剂的部分适应的一般模式的比较表明它们的气味受体的根本差异。据推测，部分适应程度的差异是由于不同的转导级联激活或气味受体的分布在个别嗅觉受体神经元。
The molecular receptors for amino acid and bile salt odorants of adult zebrafish, Danio rerio, were partially characterized using electro-olfactogram recording methods. Each of the 14 odorants tested interact with partially independent odorant receptor(s). Based on shared patterns of adaptation, cluster analysis identified two very dissimilar groups of odorants. The first group comprised the 8 amino acids with subgroups of basic, acidic and neutral amino acids. The second group comprised the 6 bile salts with subgroups of non-conjugated, taurine- and glycine-conjugated bile salts. Comparison of the general patterns of partial adaptation of amino acid and bile salt odorants suggests fundamental differences in their odorant receptors. Presumably, the differences in the extent of partial adaptation are due to differences in the transduction cascades activated or the distribution of odorant receptors on individual olfactory receptor neurons.