Mutations in tyrosine kinase and tyrosine phosphatase and their relevance to the target therapy in hematologic malignancies.
Mutations in tyrosine kinase and tyrosine phosphatase and their relevance to the target therapy in hematologic malignancies.
复制标题
DOI：
10.2217/fon.14.280
复制
发表时间：
2015-02
期刊：
影响因子：
3.3
通讯作者：
Ni Zhu;Haowen Xiao;Limengmeng Wang;Shan Fu;Chan Zhao;He Huang
中科院分区：
文献类型：
--
作者：
Ni Zhu;Haowen Xiao;Limengmeng Wang;Shan Fu;Chan Zhao;He Huang
蛋白酪氨酸激酶和蛋白酪氨酸磷酸酶在细胞磷酸化调节和信号转导中起着关键作用，具有相反的功能。越来越多的证据揭示了这两个家族成员的遗传变异与血液系统恶性肿瘤的相关性。这篇综述强调了在理解这些遗传改变的发病机制方面的进展，包括突变和异常表达，以及不断发展的蛋白酪氨酸激酶和蛋白酪氨酸磷酸酶在血液肿瘤中的靶向治疗策略。
Protein tyrosine kinases and protein tyrosine phosphatases play pivotal roles in regulation of cellular phosphorylation and signal transduction with opposite functions. Accumulating evidences have uncovered the relevance of genetic alterations in these two family members to hematologic malignancies. This review underlines progress in understanding the pathogenesis of these genetic alterations including mutations and aberrant expression and the evolving protein tyrosine kinases and protein tyrosine phosphatases targeted therapeutic strategies in hematologic neoplasms.