Endogenous digoxin-like immunoreactive factor (DLIF) serum concentrations are decreased in manic bipolar patients compared to normal controls.
Endogenous digoxin-like immunoreactive factor (DLIF) serum concentrations are decreased in manic bipolar patients compared to normal controls.
复制标题
与正常对照相比，躁狂双相情感障碍患者的内源性地高辛样免疫反应因子（DLIF）血清浓度降低。
DOI：
10.1016/s0165-0327(98)00208-0
复制
发表时间：
1999
影响因子：
6.6
通讯作者：
ValdesJr,R
中科院分区：
文献类型：
--
作者：
Grider,G;El-Mallakh,RS;Huff,MO;Buss,TJ;Miller,J;ValdesJr,R
背景红细胞钠泵活性降低与双相情感障碍躁狂发作相关。由于红细胞寿命长且缺乏细胞核，因此可能是血浆因子导致观察到的钠泵活性降低。我们检测了双相情感障碍患者和双相情感障碍患者的地高辛样免疫反应因子（DLIF）的血清浓度，并与正常对照组进行了比较。143.6±S.E.M.分别为20.94和296.6±12.76 pg地高辛当量/ml，F=4.77，P<0.05），但未与正常胸腺双相患者213.8±86.92相比，P=0.77）。躁狂和心境正常双相情感障碍患者的DLIF浓度无显著差异（P=0.8）。由于双相情感障碍患者的复发表现出季节性模式，我们还测量了12个月内该因子的血浆浓度。正常对照组的血清DLIF浓度呈季节性变化，冬季最低。双相患者的DLIF血浆浓度没有表现出季节性的模式，并保持全年低水平。LimitationsDue的非特异性抗体，我们只能测量总DLIF。此外，目前还不清楚循环DLIF的作用，如果有的话，可能是对脑function.ConclusionDLIF可能参与躁狂症的病理生理。
BackgroundA decrease in sodium pump activity in erythrocytes has been associated with manic episodes of bipolar illness relative to euthymic moods. Since red blood cells are long-lived and lack a nucleus, it is likely that a plasma factor is responsible for the observed decrease in sodium pump activity.MethodsUtilizing a radioimmunoassay, we examined the serum concentrations of the digoxin-like immunoreactive factor (DLIF) in ill and well bipolar patients and compared the values to those of normal controls.ResultsDLIF was significantly decreased in manic individuals as compared to normal controls (143.6±S.E.M. 20.94 vs 296.6±12.76 pg digoxin equivalents/ml, respectively, F=4.77, P<0.05), but not compared to euthymic bipolar subjects 213.8±86.92, P=0.77). There were no significant differences in DLIF concentrations between manic and euthymic bipolar individuals (P=0.8). Since relapse in bipolar patients appears to display a seasonal pattern, we also measured the plasma concentration of this factor over a 12-months period. Normal controls exhibited a seasonal pattern of change in serum DLIF concentrations with a nadir in the winter months. Plasma concentrations of DLIF in bipolar patients did not show a seasonal pattern and maintained low levels throughout the year.LimitationsDue to the nonspecificity of our antibody, we could measure only total DLIF. Furthermore, it is unclear what the role of circulating DLIF, if any, may be on brain function.ConclusionDLIF may be involved in the pathophysiology of mania.