Progression of left ventricular hypertrophy and the angiotensin-converting enzyme gene polymorphism in hypertrophic cardiomyopathy
Progression of left ventricular hypertrophy and the angiotensin-converting enzyme gene polymorphism in hypertrophic cardiomyopathy
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DOI：
10.1016/j.ijcard.2004.05.003
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发表时间：
2004-08-01
影响因子：
3.5
通讯作者：
Semsarian, C
中科院分区：
文献类型：
--
作者：
Doolan, G;Nguyen, L;Semsarian, C
背景：肥厚型心肌病是一种遗传性原发性心肌疾病，临床表现具有异质性。肥大的严重程度和进展速度是预后的重要因素，可能取决于年龄、致病基因突变、环境影响和遗传修饰等因素。方法：为了研究年龄对肥大进展的影响，对62例肥厚型心肌病患者进行了至少2年的随访，以确定左心室肥厚的变化基于经胸M型和二维超声心动图进行DNA研究，以确定血管紧张素转换酶（ACE）基因缺失多态性在调制左心室hypertrophy.Results的进展的作用：62例患者进行了为期6.0+/-3.2年（范围2-16年）的随访。对两个年龄组的患者数据进行分析：第1组（首次超声心动图检查时年龄小于或等于30岁的患者）的左室间隔壁厚度从23.8 ± 8.9 mm增加到28.8 ± 8.7 mm（p30岁），从17.8 ± 4.2 mm增加到19.5 ± 6.2 mm（p30岁），增加幅度较小，但具有显著性。
Background: Hypertrophic cardiomyopathy is an inherited primary disorder of the myocardium characterised by clinical heterogeneity. The severity and rate of progression of hypertrophy is an important factor in prognosis, and is likely to be dependent on factors including age, the disease-causing gene mutation, environmental influences and genetic modifiers.Methods: To study the influence of age on progression of hypertrophy, 62 patients with hypertrophic cardiomyopathy followed up for a minimum of 2 years were studied to determine the changes in left ventricular hypertrophy based on transthoracic M-mode and 2D echocardiography. DNA studies were performed to determine the role of the angiotensin-converting enzyme (ACE) gene deletion polymorphism in modulating progression of left ventricular hypertrophy.Results: Sixty-two patients were followed-up over a period of 6.0+/-3.2 years (range 2-16 years). Patient data were analysed in two age groups: group 1 (patients aged less than or equal to30 years at first echocardiogram) had an increase in left ventricular septal wall thickness from 23.8+/-8.9 to 28.8+/-8.7 mm (p30 years) had a smaller but significant increase from 17.8+/-4.2 to 19.5+/-6.2 mm (p