Experimental Evolution Reveals Antagonistic Pleiotropy in Reproductive Timing but Not Life Span in Caenorhabditis elegans
Experimental Evolution Reveals Antagonistic Pleiotropy in Reproductive Timing but Not Life Span in Caenorhabditis elegans
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DOI：
10.1093/gerona/glr143
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发表时间：
2011-12-01
影响因子：
5.1
通讯作者：
Phillips, Patrick C.
中科院分区：
文献类型：
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作者：
Anderson, Jennifer L.;Reynolds, Rose M.;Phillips, Patrick C.
在模式生物中，许多显著延长寿命的突变都伴随着巨大的适应性成本。虽然这些基因操作提供了有价值的见解分子调节寿命，目前还不清楚是否寿命延长是必然联系到健身成本。为了研究这种关系，我们进化了一个遗传异质性种群秀丽隐杆线虫47代，选择早期繁殖力。我们问是否在早期繁殖力的增加将有必要在寿命或晚期繁殖力（拮抗多效性）的减少。秀丽隐杆线虫实验进化为增加早期繁殖和减少晚期繁殖，但没有总的健身或寿命成本。鉴于这些性状之间的拮抗多效性已被证明在某些情况下，我们的结论是，遗传约束不是绝对的，也就是说，它是可能的解偶长寿从早期生育力使用遗传变异分离内和自然种群之间。
Many mutations that dramatically extend life span in model organisms come with substantial fitness costs. Although these genetic manipulations provide valuable insight into molecular modulators of life span, it is currently unclear whether life-span extension is unavoidably linked to fitness costs. To examine this relationship, we evolved a genetically heterogeneous population of Caenorhabditis elegans for 47 generations, selecting for early fecundity. We asked whether an increase in early fecundity would necessitate a decrease in longevity or late fecundity (antagonistic pleiotropy). Caenorhabditis elegans experimentally evolved for increased early reproduction and decreased late reproduction but suffered no total fitness or life-span costs. Given that antagonistic pleiotropy among these traits has been previously demonstrated in some cases, we conclude that the genetic constraint is not absolute, that is, it is possible to uncouple longevity from early fecundity using genetic variation segregating within and among natural populations.