Protection of the ischaemic myocardium by Na+/H+ exchange inhibitors:: potential mechanisms of action
Protection of the ischaemic myocardium by Na+/H+ exchange inhibitors:: potential mechanisms of action
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DOI：
10.1007/s003950170037
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发表时间：
2001-07-01
影响因子：
9.5
通讯作者：
Avkiran, M
中科院分区：
文献类型：
--
作者：
Avkiran, M
本文重点介绍钠/氢交换器（NHE）抑制剂在缺血和再灌注期间保护心肌完整性和功能的细胞机制。增加肌膜NHE活性，所产生的细胞外pH值的快速正常化。在一个长期的缺血，NHE活性预计将是高缺血发作后不久。再灌注早期细胞外pH值的快速正常化有望解除对肌膜NHE的抑制并导致进一步损伤。
The article focuses on the cellular mechanisms through which sodium/hydrogen exchanger (NHE) inhibitors may preserve myocardial integrity and function during ischaemia and reperfusion. Increased sarcolemmal NHE activity, arising from the rapid normalisation of extracellular pH. During a prolonged period of ischaemia, NHE activity would be expected to be high soon after the onset of ischaemia. The rapid normalization of extracellular pH during early reperfusion would be expected to disinhibit the sarcolemmal NHE and lead to further injury.