Postoperative Intensive Care Unit Drug Fever Caused by Dexmedetomidine
Postoperative Intensive Care Unit Drug Fever Caused by Dexmedetomidine
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DOI：
10.1213/ane.0b013e31819f1985
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发表时间：
2009-05-01
影响因子：
5.7
通讯作者：
Sakamoto, Atsuhiro
中科院分区：
文献类型：
--
作者：
Okabe, Tadashi;Takeda, Shinhiro;Sakamoto, Atsuhiro
盐酸右美托咪定是一种高效、高选择性的α-2肾上腺素能受体激动剂，广泛用于重症监护病房的镇静药物。我们描述了一例59岁的患者，他经历了由盐酸右美托咪定引起的药物热。患者因腹主动脉瘤破裂被转至重症监护室。在开始使用盐酸右美托咪定镇静后，他出现了39℃以上的发热，这种症状在停用盐酸右美托咪定7小时后迅速改善。其他可能的原因(如感染)被顺序消除。
Dexmedetomidine hydrochloride is a potent, highly selective alpha-2 adrenergic receptor agonist, broadly used as a sedative drug in intensive care units. We describe the case of a 59-yr-old patient who experienced drug fever caused by dexmedetomidine hydrochloride. The patient was transferred to the intensive care unit with an abdominal aortic aneurysm rupture. After initiation of sedation with dexmedetomidine hydrochloride, he developed pyrexia of more than 39 degrees C. This symptom improved rapidly 7 h after stopping dexmedetomidine hydrochloride. Other possible causes (such as infection) were sequentially eliminated.