Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity
Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity
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DOI：
10.1126/science.283.5400.397
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发表时间：
1999-01-15
期刊：
影响因子：
--
通讯作者：
Caron, Marc G.
中科院分区：
文献类型：
--
作者：
Gainetdinov, Raul R.;Wetsel, William C.;Caron, Marc G.
精神兴奋剂对患有注意力缺陷多动障碍（ADHD）或多动障碍的人起到镇静作用的机制目前尚不清楚。缺乏编码质膜多巴胺转运蛋白（DAT）基因的小鼠多巴胺能张力升高，表现为过度活跃。暴露在新的环境中会加剧这种活动。此外，这些小鼠的空间认知功能受损，它们对精神兴奋剂的反应显示出运动减少。精神兴奋剂的这种矛盾的镇静作用依赖于血清素能神经传递。DAT基因敲除小鼠和ADHD个体之间的相似之处表明，它们的一些行为和对精神兴奋剂的反应可能存在共同的机制。
The mechanism by which psychostimulants act as calming agents in humans with attention-deficit hyperactivity disorder (ADHD) or hyperkinetic disorder is currently unknown. Mice lacking the gene encoding the plasma membrane dopamine transporter (DAT) have elevated dopaminergic tone and are hyperactive. This activity was exacerbated by exposure to a novel environment. Additionally, these mice were impaired in spatial cognitive function, and they showed a decrease in locomotion in response to psychostimulants. This paradoxical calming effect of psychostimulants depended on serotonergic neurotransmission. The parallels between the DAT knockout mice and individuals with ADHD suggest that common mechanisms may underlie some of their behaviors and responses to psychostimulants.