Partial EMT/MET: An Army of One
Partial EMT/MET: An Army of One
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DOI：
10.1007/978-1-0716-0779-4_5
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发表时间：
2021-01-01
期刊：
影响因子：
--
通讯作者：
Sheng, Guojun
中科院分区：
文献类型：
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作者：
Hamidi, Sofiane;Nagai, Hiroki;Sheng, Guojun
随着我们对上皮间充质转化（EMT）的了解增加，E与M的原始二元概念不再符合实验证据。将EMT范式重新定义为完整上皮和完整间充质之间的光谱转换表明存在虚拟无限的中间细胞状态。新的挑战是开发所需的技术工具，将这些状态中的每一个置于背景中，并确定生物学上重要的细胞机制，这些机制可以用于对抗EMT相关疾病。
As our understanding of Epithelial Mesenchymal Transition (EMT) increases, the original binary concept of E versus M no longer fits with experimental evidence. Re-definition of the EMT paradigm as spectral transitions between a full epithelium and a full mesenchyme suggests the existence of a virtual infinity of intermediate cellular states. The new challenge is to develop technical tools needed to contextualize each of these states and identify biologically significant cellular mechanisms that could be targeted in combatting EMT-related diseases.