Social support and salivary cortisol in women with metastatic breast cancer
Social support and salivary cortisol in women with metastatic breast cancer
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DOI：
10.1097/00006842-200005000-00007
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发表时间：
2000-05-01
影响因子：
3.3
通讯作者：
Spiegel, D
中科院分区：
文献类型：
--
作者：
Turner-Cobb, JM;Sephton, SE;Spiegel, D
目的：本研究采用横断面研究设计，探讨社会支持、数量、（人数）和质量（评价，归属感，有形和自尊）和神经内分泌功能（昼夜唾液皮质醇的平均值和斜率）;方法：参与者（N = 103）来自一项研究（N = 125），该研究探讨了团体治疗对转移性乳腺癌女性的情绪调节和健康的影响。他们完成了人际支持评估表和耶鲁社会支持指数，并提供唾液样本，以评估连续3天的每日皮质醇水平。使用对数转换的皮质醇浓度计算昼夜平均水平，并通过对数转换的皮质醇浓度对样本采集时间的回归计算皮质醇昼夜变化的斜率。结果如下：平均唾液皮质醇呈负相关的评价，归属感和有形的社会支持的人际支持评价列表分量表。没有发现定量支持或自尊分量表的人际支持评价列表和平均唾液皮质醇之间的关联。定性和定量的社会支持措施与昼夜皮质醇斜率无关。结论：结果表明，更高质量的社会支持与转移性乳腺癌妇女的皮质醇浓度较低有关，这表明神经内分泌功能更健康。这些结果可能对乳腺癌的治疗具有临床意义。
Objective: This study used a cross-sectional design to examine the relationships between social support, both quantity (number of people) and quality (appraisal, belonging, tangible, and self-esteem), and neuroendocrine function (mean and slope of diurnal salivary cortisol) among women with metastatic breast cancer; Methods: Participants (N = 103) were drawn from a study (N = 125) of the effects of group therapy on emotional adjustment and health in women with metastatic breast cancer. They completed the Interpersonal Support Evaluation List and the Yale Social Support Index and provided saliva samples for assessment of diurnal cortisol levels on each of 3 consecutive days. Diurnal mean levels were calculated using log-transformed cortisol concentrations, and the slope of diurnal cortisol variation was calculated by regression of log-transformed cortisol concentrations on sample collection time. Results: Mean salivary cortisol was negatively related to the Interpersonal Support Evaluation List subscales of appraisal, belonging, and tangible social support. No association was found between quantitative support or the esteem subscale of the Interpersonal Support Evaluation List and mean salivary cortisol. Measures of qualitative and quantitative social support were not associated with the diurnal cortisol slope. Conclusions: Results show that greater quality of social support is associated with lower cortisol concentrations in women with metastatic breast cancer, which is indicative of healthier neuroendocrine functioning. These results may have clinical implications in the treatment of breast cancer.