The effect of age on longitudinal measures of beta cell function and insulin sensitivity during the progression of early stage type 1 diabetes.
The effect of age on longitudinal measures of beta cell function and insulin sensitivity during the progression of early stage type 1 diabetes.
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DOI：
10.1007/s00125-022-05836-w
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发表时间：
2023-03
期刊：
影响因子：
8.2
通讯作者：
Evans-Molina, Carmella
中科院分区：
文献类型：
--
作者：
Ferrannini, Ele;Mari, Andrea;Monaco, Gabriela S. F.;Skyler, Jay S. S.;Evans-Molina, Carmella
The risk of progressing from autoantibody positivity to type 1 diabetes is inversely related to age. Separately, whether age influences patterns of C-peptide loss or changes in insulin sensitivity in autoantibody-positive individuals who progress to stage 3 type 1 diabetes is unclear. Beta cell function and insulin sensitivity were determined by modelling of OGTTs performed in 658 autoantibody-positive participants followed longitudinally in the Diabetes Prevention Trial–Type 1 (DPT-1). In this secondary analysis of DPT-1 data, time trajectories of beta cell function and insulin sensitivity were analysed in participants who progressed to type 1 diabetes (progressors) to address the impact of age on patterns of metabolic progression to diabetes. Among the entire DPT-1 cohort, the highest discriminant age for type 1 diabetes risk was 14 years, with participants aged <14 years being twice as likely to progress to type 1 diabetes as those aged ≥14 years. At study entry, beta cell glucose sensitivity was impaired to a similar extent in progressors aged <14 years and progressors aged ≥14 years. From study entry to stage 3 type 1 diabetes onset, beta cell glucose sensitivity and insulin sensitivity declined in both progressor groups. However, there were no significant differences in the yearly rate of decline in either glucose sensitivity (−13.7 [21.2] vs −11.9 [21.5] pmol min−1 m−2 [mmol/l]−1, median [IQR], p=0.52) or insulin sensitivity (−22 [37] vs −14 [40] ml min−1 m−2, median [IQR], p=0.07) between progressors aged <14 years and progressors aged ≥14 years. Our data indicate that during progression to stage 3 type 1 diabetes, rates of change in declining glucose and insulin sensitivity are not significantly different between progressors aged <14 years and progressors aged ≥14 years. These data suggest there is a predictable course of declining metabolic function during the progression to type 1 diabetes that is not influenced by age. The online version contains peer-reviewed but unedited supplementary material available at 10.1007/s00125-022-05836-w.
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影响因子：
7.7
作者：
Ferrannini, Ele;Mari, Andrea;Skyler, Jay S.
通讯作者：
Skyler, Jay S.
影响因子：
7.7
作者：
Linsley PS;Greenbaum CJ;Nepom GT
通讯作者：
Nepom GT
影响因子：
158.5
作者：
Herold, Kevan C.;Bundy, Brian N.;Greenbaum, Carla J.
通讯作者：
Greenbaum, Carla J.
DOI：
10.1152/ajpendo.00175.2004
发表时间：
2005-03-01
影响因子：
5.1
作者：
Mari, A;Gastaldelli, A;Ferrannini, E
通讯作者：
Ferrannini, E
影响因子：
16.2
作者：
Bogun, Magdalena M.;Bundy, Brian N.;Greenbaum, Carla J.
通讯作者：
Greenbaum, Carla J.