Synthesis of 5-Fluorotriazoles by Silver-Mediated Fluorination of 5-Iodotriazoles
Synthesis of 5-Fluorotriazoles by Silver-Mediated Fluorination of 5-Iodotriazoles
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银介导的 5-碘三唑氟化合成 5-氟三唑
DOI：
10.1002/ejoc.201500338
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发表时间：
2015
影响因子：
2.8
通讯作者：
Chu Taiwei
中科院分区：
文献类型：
--
作者：
Wang Damin;Sun Wenjing;Chu Taiwei
建立了一种以AGF为氟源，N_1，N_1，N_2，N_2-四甲基乙烷-1，2-二胺(TMEDA)为配体的5-碘三唑直接氟化反应的简便方法。该方法与各种官能团相容。4位没有芳基或N1位没有脂肪族取代基的5-碘三唑也可以顺利转化为相应的5-氟三唑。还进行了初步的机理研究。
A simple method was developed for the direct fluorination of 5‐iodotriazoles with AgF as fluoride source andN1,N1,N2,N2‐tetramethylethane‐1,2‐diamine (TMEDA) as ligand. This method is compatible with various functional groups. 5‐Iodotriazoles without aromatic groups at the 4‐position or aliphatic substituents at the N1 position can also be smoothly converted to the corresponding 5‐fluorotriazoles. Preliminary mechanism studies were also performed.