Synthesis of (+),(-)-neamine and their positional isomers as potential antibiotics.
Synthesis of (+),(-)-neamine and their positional isomers as potential antibiotics.
复制标题
作为潜在抗生素的( ),(-)-新胺及其位置异构体的合成。
DOI：
10.1016/s0960-894x(02)01073-9
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发表时间：
2003
影响因子：
2.7
通讯作者：
Rando,RobertR
中科院分区：
文献类型：
--
作者：
Ryu,DoHyun;Tan,Choon-Hong;Rando,RobertR
合成了（+）-新霉胺1、（-）-新霉胺ent-1及其位置异构体2、3、ent-2和ent-3，它们是潜在的新型氨基糖苷类抗生素的新支架。这些异构体表现出相似的抑制活性，如使用体外翻译测定所示。提出了一个简单的模型来解释这种缺乏立体特异性结合的核糖体RNA。
The syntheses of (+)-neamine 1, (−)-neamine ent-1 and their positional isomers 2, 3, ent-2 and ent-3 are reported as potential new scaffolds for novel aminoglycoside antibiotics. These isomers exhibit similar inhibitory activities, as shown using an in vitro translation assay. A simple model is proposed to explain this lack of stereospecific binding to the ribosomal RNA.