EFFECTS OF HYPERTHERMIA ON NORMAL AND TUMOR MICRO-ENVIRONMENT
EFFECTS OF HYPERTHERMIA ON NORMAL AND TUMOR MICRO-ENVIRONMENT
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DOI：
10.1148/radiology.137.2.7433686
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发表时间：
1980-01-01
期刊：
影响因子：
19.7
通讯作者：
OBRIEN, T
中科院分区：
文献类型：
--
作者：
BICHER, HI;HETZEL, FW;OBRIEN, T
本文研究了热疗对几种正常和肿瘤组织[人肿瘤和小鼠乳腺癌细胞]的pH值、局部血流量(LBF)和组织氧分压(TpO2)的影响。TpO2、LBF和pH在肿瘤组织中明显不均匀。TpO2在某些区域非常低，这些区域似乎也失去了血液流动，并且处于非常低的PH值。体温过高有双重作用。温度低于41度。增加血流量和TpO2；在41度以上。它会导致血流崩溃，TpO2降低，组织pH值从肿瘤中已经很低的pH值向酸中毒转变。
The effects of hyperthermia [for cancer therapy] on pH, local blood flow (LBF) and tissue oxygen tension (TpO2) in several normal and tumor tissues [human tumors and mouse mammary adenocarcinoma C3H cells] were studied. TpO2, LBF and pH apparently are inhomogeneous in tumor tissue. TpO2 is very low in certain areas which also seem deprived of blood flow and are at very low pH. Hyperthermia has a dual effect. At temperatures below 41.degree. C, it increases blood flow and TpO2; above 41.degree. C, it causes a collapse in blood flow, lower TpO2 and a shift of the tissue pH towards acidosis from the already low pH values found in tumors.