THE PROLIFERATION OF MAP KINASE SIGNALING PATHWAYS IN YEAST
THE PROLIFERATION OF MAP KINASE SIGNALING PATHWAYS IN YEAST
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DOI：
10.1016/0955-0674(95)80028-x
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发表时间：
1995-04-01
影响因子：
7.5
通讯作者：
ERREDE, B
中科院分区：
文献类型：
--
作者：
LEVIN, DE;ERREDE, B
有丝分裂原活化蛋白激酶在酵母中至少在五种生理上不同的信号通路中起作用。这些包括介导对交配信息素的反应、假菌丝发育和侵入性生长、细胞完整性、孢子形成和对高细胞外渗透压的反应的途径。这些激酶及其上游活化激酶包含信号传导模块，其在至少一些情况下作为多蛋白复合物存在。过去一年的研究表明，交配信息素反应途径中的Ste5蛋白作为一个支架，促进该途径中蛋白激酶之间的相互作用，并阻止它们与其他模块的激酶相互作用。
Mitogen-activated protein kinases function in at least five, physiologically distinct, signaling pathways in yeast. These include pathways that mediate response to mating pheromone, pseudohyphal development and invasive growth, cell integrity, sporulation, and response to high extracellular osmolarity. These kinases and their upstream activating kinases comprise signaling modules that, in at least some cases, exist as multiprotein complexes. Studies during the past year have revealed that the Ste5 protein of the mating pheromone response pathway serves as a scaffold to promote interactions among the protein kinases in this pathway, and to prevent their interaction with kinases of other modules.