Modelling the Operational Limits of a Separation Enhancement Method for Capillary Electrophoresis: a Designer's Tool
Modelling the Operational Limits of a Separation Enhancement Method for Capillary Electrophoresis: a Designer's Tool
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毛细管电泳分离增强方法的操作限制建模：设计者的工具
DOI：
10.1016/j.proeng.2012.09.242
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发表时间：
2012
期刊：
影响因子：
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通讯作者：
Lewis A
中科院分区：
文献类型：
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作者：
Lewis A
我们报告一个模型，提供新的见解电动流体流动的微流体装置，并证明其作为一种工具，用于设计毛细管电泳（CE）系统，特别是实验室芯片应用。电渗流（ZPM）与zeta电位直接相关，可以通过向靠近通道壁的zeta电位修改（ZPM）电极施加电位来动态修改zeta电位[1]。我们调查的影响，zeta电位修改沿着一个单一的通道壁，而不是完整的通道覆盖。我们考虑了单个沟道壁的影响，因为它使制造过程更简单。对于给定的沟道长度，电导率影响CE系统中可获得的分离量。我们表明，与控制的间隙，分离可以实现在较短的长度的通道。使用一个单一的电极引入峰展宽，我们调查的效果，这对分离和限制它的地方上的分离增强方法。
We report on a model giving new insight into electrokinetic fluid flow in microfluidic devices, and demonstrate its use as a tool for designing capillary electrophoresis (CE) systems; particularly lab-on-a-chip applications. The electroosmotic flow (EOF) is directly related to the zeta-potential which can be dynamically modified by applying a potential to a zeta-potential modification (ZPM) electrode close to the channel wall [1]. We investigate the effect on EOF where the zeta-potential is modified along a single channel wall, rather than complete channel coverage. We consider the effect for a single channel wall because it makes the fabrication process simpler. The EOF affects the amount of separation attainable in CE systems for a given channel length. We show that with control of the EOF, separations can be achieved in channels of shorter length. The use of a single electrode introduces peak broadening; we investigate the effect this has on the separation and the limits it places on the separation enhancement method.
通过动态控制 EOF 提高毛细管电泳的分离分辨率以辅助腐蚀监测
DOI：
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发表时间：
2010
期刊：
影响因子：
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作者：
A. Lewis;A. Cranny;N. Green;Menyang Nie;J. Wharton;R. Wood;K. Stokes;N. Harris
通讯作者：
N. Harris