Cis-regulatory RNA elements that regulate specialized ribosome activity.
Cis-regulatory RNA elements that regulate specialized ribosome activity.
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调节特殊核糖体活性的顺式调节 RNA 元件。
DOI：
10.1080/15476286.2015.1085149
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发表时间：
2015
期刊：
影响因子：
4.1
通讯作者：
Barna,Maria
中科院分区：
文献类型：
--
作者：
Xue,Shifeng;Barna,Maria
最近的证据表明，核糖体本身可以在特定的mRNA亚池的专门翻译中发挥高度调节作用，特别是在核糖体蛋白（RP）水平。然而，对这种选择的机制仍然知之甚少。在我们最近的研究中，我们在mRNA的5′ UTR中发现了一种独特的RNA元件组合，允许核糖体进行这种控制。这些mRNA含有抑制一般帽依赖性翻译的翻译抑制元件（TIE）和依赖于特定RP进行激活的内部核糖体进入位点（IRES）。一般翻译的抑制剂和专门翻译的激活剂的独特组合是核糖体介导的基因表达控制的关键。在这里，我们将讨论这些RNA调控元件如何提供一个新的水平的控制蛋白质的表达及其对基因表达，生物体发育和进化的影响。
Recent evidence has shown that the ribosome itself can play a highly regulatory role in the specialized translation of specific subpools of mRNAs, in particular at the level of ribosomal proteins (RP). However, the mechanism(s) by which this selection takes place has remained poorly understood. In our recent study, we discovered a combination of unique RNA elements in the 5′UTRs of mRNAs that allows for such control by the ribosome. These mRNAs contain a Translation Inhibitory Element (TIE) that inhibits general cap-dependent translation, and an Internal Ribosome Entry Site (IRES) that relies on a specific RP for activation. The unique combination of an inhibitor of general translation and an activator of specialized translation is key to ribosome-mediated control of gene expression. Here we discuss how these RNA regulatory elements provide a new level of control to protein expression and their implications for gene expression, organismal development and evolution.