A case of Schizophyllum commune sinusitis following unrelated cord blood transplantation for acute lymphoblastic leukemia.
A case of Schizophyllum commune sinusitis following unrelated cord blood transplantation for acute lymphoblastic leukemia.
复制标题
因急性淋巴细胞白血病进行无关脐带血移植后发生裂褶菌社区性鼻窦炎的一例。
DOI：
10.1007/s12185-013-1362-4
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Kurokawa M
中科院分区：
文献类型：
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作者：
Toya T;Shinohara A;Tatsuno K;Seo S;Nannya Y;Ichikawa M;Makirnura K Moriya K;Kurokawa M
Schizophyllum communees是一种全球分布的担子菌真菌，被认为是鼻窦炎的罕见病因，目前尚无及时的治疗方法。我们描述了s。急性淋巴细胞白血病非相关脐带血移植后感染性鼻窦炎。移植后13天，一名23岁女性出现上颌窦炎和筛窦炎。鼻窦炎耐药，鼻窦抽吸培养显示白色羊毛霉菌，经核酸测序鉴定为as .群落。患者静脉给予两性霉素B脂质体治疗2个月，随后口服伏立康唑。本报告提示两性霉素B脂质体和伏立康唑治疗s的有效性。免疫功能低下患者的社区感染。考虑到区分的困难。标准培养法测定社区感染曲霉病的发生率。异体造血干细胞移植后的社区感染可能被低估。核苷酸测序可能有助于s的诊断。communeinfection。
Schizophyllum communeis a globally distributed basidiomycete fungus that is known as a rare cause of sinusitis, for which no prompt treatment has been established. We describe the first report ofS. communesinusitis following unrelated cord blood transplantation for acute lymphoblastic leukemia. Thirteen days after transplantation, a 23-year-old female developed maxillary and ethmoid sinusitis. The sinusitis was antimicrobial-resistant, and the sinus aspirate culture revealed white wooly mold, which was identified asS. communeby nucleotide sequencing. The patient was successfully treated with intravenous administration of liposomal amphotericin B for 2 months, followed by oral voriconazole. This report suggests the effectiveness of liposomal amphotericin B and voriconazole forS. communeinfection in immunocompromised patients. Given the difficulty in distinguishingS. communeinfection from aspergillosis by standard culture methods, the incidence ofS. communeinfection following allogeneic hematopoietic stem cell transplantation may be underestimated. Nucleotide sequencing may be useful in the diagnosis ofS. communeinfection.