Working memory and pattern separation in founder strains of the BXD recombinant inbred mouse panel.
Working memory and pattern separation in founder strains of the BXD recombinant inbred mouse panel.
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DOI：
10.1038/s41598-021-03850-3
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发表时间：
2022-01-07
影响因子：
4.6
通讯作者：
Mittleman G
中科院分区：
文献类型：
--
作者：
Dickson PE;Mittleman G
工作记忆和模式分离是基本的认知能力，当受损时，会显着降低生活质量。发现这些认知能力的先天和疾病引起的变异背后的遗传机制是治疗阿尔茨海默病等常见和破坏性神经退行性疾病的关键一步。在这方面，试验独特的位置不匹配试验（TUNL）是一种触摸屏操作性条件反射程序，可以同时定量小鼠和大鼠的工作记忆和模式分离。在本研究中，我们使用TUNEL测定来量化C57 BL/6 J和DBA/2 J小鼠的这些认知能力。这些品系是BXD重组近交系小鼠组的创建者，其能够发现表型变异的遗传机制。TUNEL测试表明，模式分离的小鼠应变显着影响，而工作记忆没有。此外，水平距离和垂直距离的选择相位刺激之间的影响，有分离的TUNL性能。这些研究结果提供了新的数据，小鼠品系差异的模式分离和支持先前的研究结果相同的工作记忆性能在C57 BL/6 J和DBA/2 J小鼠。虽然在本研究中BXD创始菌株的工作记忆是相当的，BXD菌株的工作记忆可能是不同的，因为超亲分离。总的来说，这里提供的数据表明，模式分离在小鼠中是可遗传的，并且BXD面板可用于识别模式分离中的潜在变化机制。
Working memory and pattern separation are fundamental cognitive abilities which, when impaired, significantly diminish quality of life. Discovering genetic mechanisms underlying innate and disease-induced variation in these cognitive abilities is a critical step towards treatments for common and devastating neurodegenerative conditions such as Alzheimer's disease. In this regard, the trial-unique nonmatching-to-location assay (TUNL) is a touchscreen operant conditioning procedure allowing simultaneous quantification of working memory and pattern separation in mice and rats. In the present study, we used the TUNL assay to quantify these cognitive abilities in C57BL/6J and DBA/2J mice. These strains are the founders of the BXD recombinant inbred mouse panel which enables discovery of genetic mechanisms underlying phenotypic variation. TUNL testing revealed that pattern separation was significantly influenced by mouse strain, whereas working memory was not. Moreover, horizontal distance and vertical distance between choice-phase stimuli had dissociable effects on TUNL performance. These findings provide novel data on mouse strain differences in pattern separation and support previous findings of equivalent working memory performance in C57BL/6J and DBA/2J mice. Although working memory of the BXD founder strains was equivalent in this study, working memory of BXD strains may be divergent because of transgressive segregation. Collectively, data presented here indicate that pattern separation is heritable in the mouse and that the BXD panel can be used to identify mechanisms underlying variation in pattern separation.
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DOI：
10.1016/j.ijdevneu.2019.06.009
发表时间：
2019-11-01
影响因子：
1.8
作者：
Bagley, Jared R.;Adams, Julia;Kippin, Tod E.
通讯作者：
Kippin, Tod E.
影响因子：
3
作者：
Dickson, Price E.;Mittleman, Guy
通讯作者：
Mittleman, Guy
影响因子：
24.8
作者：
D'Esposito M;Postle BR
通讯作者：
Postle BR
影响因子：
7.3
作者：
Bagley, Jared R.;Szumlinski, Karen K.;Kippin, Tod E.
通讯作者：
Kippin, Tod E.
影响因子：
9.3
作者：
Ashbrook DG;Arends D;Prins P;Mulligan MK;Roy S;Williams EG;Lutz CM;Valenzuela A;Bohl CJ;Ingels JF;McCarty MS;Centeno AG;Hager R;Auwerx J;Lu L;Williams RW
通讯作者：
Williams RW