Effect of age on anterior chamber angle configuration in Asians determined by anterior segment optical coherence tomography; clinic-based study
Effect of age on anterior chamber angle configuration in Asians determined by anterior segment optical coherence tomography; clinic-based study
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DOI：
10.1111/j.1755-3768.2010.01960.x
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发表时间：
2010-09-01
影响因子：
3.4
通讯作者：
Kook, Michael S.
中科院分区：
文献类型：
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作者：
Cheon, Mi Hyun;Sung, Kyung Rim;Kook, Michael S.
目的：评估亚洲受试者前房角 (ACA) 参数的分布，并评估这些参数与年龄的关联。方法：从大学诊所连续招募了 439 名年龄在 30 至 89 岁的韩国受试者。所有参与者均使用眼前节光学相干断层扫描（AS-OCT，Visante，2.0 版）进行扫描。我们测量了 ACA 参数，例如前房深度 (ACD)、500 和 750 μm 处的房角开口距离 (AOD(500,750))、500 和 750 μm 处的房角隐窝面积 (ARA(500,750))、500 和 750 μm 处的小梁虹膜间隙面积 (TISA(500,750))，并确定这些参数与年龄相关的变化。使用线性混合效应模型调整参数，该模型根据性别、眼轴长度、眼压和角膜曲率测量数据进行调整。确定了 ACA 参数随年龄变化的斜率。对于各种 AS-OCT 参数，通过将斜率除以平均值来计算归一化斜率。结果：所有分析的 ACA 参数在鼻象限和颞象限中都随着年龄的增长而下降。眼轴长度和角膜曲率测量数据是 ACA 变化的重要协变量。在颞角测量的ACD的斜率是-0.02396毫米/年，AOD(500)、ARA(500)和TISA(500)的斜率分别是-0.00634毫米/年、-0.0019毫米2/年和-0.00177毫米2/年。中央角膜厚度不存在年龄依赖性差异（p 值；0.4597）。根据标准化斜率，AOD 在颞区和鼻区显示出最陡的斜率。结论：通过 AS-OCT 评估的所有 ACA 参数（考虑了其他眼部生物特征参数）随着年龄的增加显示出显着的负斜率。在评估前房随时间的变化时应考虑这些结果。
Purpose:To evaluate the distribution of anterior chamber angle (ACA) parameters and to assess association of these parameters with age in Asian subjects.Methods:Four hundred and thirty-nine consecutive Korean subjects aged from 30 to 89 were enrolled from a university clinic. All participants were scanned using anterior segment optical coherence tomography (AS-OCT, Visante, version 2.0). We measured ACA parameters such as anterior chamber depth (ACD), angle opening distance at 500 and 750 mu m (AOD(500,750)), angle recess area at 500 and 750 mu m (ARA(500,750)), trabecular iris space area at 500 and 750 mu m (TISA(500,750)), and determined age-related changes in these parameters with use of a linear mixed effect model that adjusted for gender, axial length, intraocular pressure, and keratometry data. Slopes of ACA parameters as a function of age were determined. For various AS-OCT parameters, the normalized slope was calculated by dividing the slope by the mean value.Results:All analysed ACA parameters decreased with age in both nasal and temporal quadrants. Axial length and keratometry data were significant covariates for ACA changes. The slopes of ACD were -0.02396 mm/year, AOD(500), ARA(500), and TISA(500) measured at the temporal angle were -0.00634 mm/year, -0.0019 mm2/year, and -0.00177 mm2/year, respectively. There was no age-dependent difference in central corneal thickness (p value; 0.4597) Based on the normalized slopes, the AOD showed the steepest slope at both temporal and nasal sectors.Conclusion:All ACA parameters assessed by AS-OCT, which accounted for other ocular biometric parameters, showed significant negative slopes with increasing age. These results should be considered when assessing changes in the anterior chamber over time.