Focalized proteolysis: Spatial and temporal regulation of extracellular matrix degradation at the cell surface
Focalized proteolysis: Spatial and temporal regulation of extracellular matrix degradation at the cell surface
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DOI：
10.1016/s0955-0674(96)80116-5
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发表时间：
1996-10-01
影响因子：
7.5
通讯作者：
Werb, Z
中科院分区：
文献类型：
--
作者：
Basbaum, CB;Werb, Z
细胞通过改变细胞表面和细胞外基质蛋白来响应微环境的变化。这些蛋白质可能通过蛋白水解的降解或激活而发生快速且不可逆的变化。通过将蛋白水解事件集中在细胞表面或附近，即使存在高浓度抑制剂，这些过程也可以有效。越来越多的证据表明，分泌型和跨膜基质金属蛋白酶、金刚蛋白和虾红素（tolloid）家族的金属蛋白酶以及丝氨酸蛋白酶在发育、分化、细胞运动和侵袭以及细胞外决策中至关重要。
Cells respond to changes in their microenvironment by altering their cell surface and extracellular matrix proteins. Rapid and irreversible changes in these proteins are possible through their degradation or activation by proteolysis. By focalizing the proteolytic events at or near the cell surface, these processes can be effective even in the presence of high concentrations of inhibitors. Evidence is emerging that secreted and transmembrane matrix metalloproteinases, metalloproteinases of the adamalysin and astacin (tolloid) families, and serine proteinases are crucial in development, differentiation, cell motility and invasion, and cell-extracellular decisions.