Principles of recovery from traumatic brain injury: Reorganization of functional networks
Principles of recovery from traumatic brain injury: Reorganization of functional networks
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DOI：
10.1016/j.neuroimage.2010.12.046
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发表时间：
2011-04-01
期刊：
影响因子：
5.7
通讯作者：
del-Pozo, Francisco
中科院分区：
文献类型：
--
作者：
Castellanos, Nazareth P.;Leyva, Inmaculada;del-Pozo, Francisco
脑损伤后的恢复是研究脑可塑性和网络重组机制的绝佳平台。复杂网络测量是否能捕捉到创伤性脑损伤及其恢复后发生的生理和认知变化？患者以及对照组进行静息状态脑磁图记录损伤后和神经康复后。然后，计算了网络强度、路径长度、效率、聚类和能量成本等网络度量。我们发现，在许多情况下，这些参数恢复到恢复后的控制值，特别是在δ和α波段，我们设计了一个模型，给出了一些关于功能网络如何在恢复过程中修改其权重的提示。正相关的复杂网络措施和WAIS-III测试的一些一般指标之间的关系被发现：基于德尔塔的路径长度的变化和那些在性能智商得分，和基于阿尔法的归一化的全球效率和感知组织指数。这些结果表明：1）恢复的原则取决于光谱带，2）功能网络的结构与脑恢复平行地演变，并与神经心理量表相关，3）能量成本揭示了恢复的最佳原则。(C)2010年爱思唯尔公司All rights reserved.
Recovery after brain injury is an excellent platform to study the mechanism underlying brain plasticity, the reorganization of networks. Do complex network measures capture the physiological and cognitive alterations that occurred after a traumatic brain injury and its recovery? Patients as well as control subjects underwent resting-state MEG recording following injury and after neurorehabilitation. Next, network measures such as network strength, path length, efficiency, clustering and energetic cost were calculated. We show that these parameters restore, in many cases, to control ones after recovery, specifically in delta and alpha bands, and we design a model that gives some hints about how the functional networks modify their weights in the recovery process. Positive correlations between complex network measures and some of the general index of the WAIS-III test were found: changes in delta-based path-length and those in Performance IQ score, and alpha-based normalized global efficiency and Perceptual Organization Index. These results indicate that: 1) the principle of recovery depends on the spectral band, 2) the structure of the functional networks evolves in parallel to brain recovery with correlations with neuropsychological scales, and 3) energetic cost reveals an optimal principle of recovery. (C) 2010 Elsevier Inc. All rights reserved.