Photochemical Conversion of Isoxazoles to 5-Hydroxyimidazolines
Photochemical Conversion of Isoxazoles to 5-Hydroxyimidazolines
复制标题
异恶唑光化学转化为 5-羟基咪唑啉
DOI：
10.1021/acs.orglett.0c00910
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发表时间：
2020
期刊：
影响因子：
5.2
通讯作者：
Nakamura Hiroyuki
中科院分区：
文献类型：
--
作者：
Morita Taiki;Fuse Shinichiro;Nakamura Hiroyuki
在紫外光照射下，异恶唑I的光化学转化为5-羟基咪唑啉VII进行通过捕获的光生成的酰基咪唑啉III胺。这是第一次报告的有效合成5-羟基咪唑啉，是不容易获得的其他手段。5-通过用三氟乙酸酐（TFAA）和2，6-二甲基吡啶在二氯甲烷中处理，羟基咪唑啉也可以一步转化为多取代的咪唑。
Photochemical conversion of isoxazoleIto 5-hydroxyimidazolineVIIproceeded via the trapping of the photogenerated acylazirineIIIwith amines under UV light irradiation. This is the first report of the efficient synthesis of 5-hydroxyimidazolines that are not readily accessible by other means. 5-Hydroxyimidazolines were also converted into multisubstituted imidazoles in one step by treatment with trifluoroacetic anhydride (TFAA) and 2,6-lutidine in dichloromethane.