ROLE OF FIBRIN DEPOSITION IN THE PATHOGENESIS OF INTRAABDOMINAL INFECTION
ROLE OF FIBRIN DEPOSITION IN THE PATHOGENESIS OF INTRAABDOMINAL INFECTION
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DOI：
10.1007/bf01967800
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发表时间：
1992-11-01
影响因子：
4.5
通讯作者：
ROTSTEIN, OD
中科院分区：
文献类型：
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作者：
ROTSTEIN, OD
细菌性渗出物的产生在决定腹膜感染的结果中起重要作用。大量细菌被隔离在纤维蛋白基质内，从而延缓细菌在整个腹膜腔中扩散并进入血流。这种隔离过程在目的论上是有利的，因为它减少了早期的快速死亡。最近的研究表明，这一过程可能是腹膜残余感染发展的一个组成部分。隔离在纤维蛋白沉积物中的细菌受到保护，不受正常宿主清除机制的影响，从而允许无抵抗的增殖并最终形成脓肿。全面了解宿主对腹膜感染反应的细胞和非细胞方面将提出治疗和预防腹腔内脓肿及其伴随后果的发展的新策略。
The production of fibrinous exudates plays an important role in determining the outcome of peritoneal infection. Large numbers of bacteria are sequestered within fibrin matrices, thereby retarding bacterial spread throughout the peritoneal cavity and into the bloodstream. This walling-off process is teleologically advantageous in that it lessens early rapid mortality. Recent studies have documented that this same process is probably integral to the development of residual infection in the peritoneum. Bacteria sequestered within fibrin deposits are protected from normal host clearance mechanisms, thereby permitting unopposed proliferation and ultimately the establishment of an abscess. A complete understanding of the cellular and noncellular aspects of the host response to peritoneal infection will suggest novel strategies both to treat and to prevent the development of intraabdominal abscesses and their attendant consequences.