Human listeriosis and animal models
Human listeriosis and animal models
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DOI：
10.1016/j.micinf.2007.05.009
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发表时间：
2007-08-01
影响因子：
5.8
通讯作者：
Lecuit, Marc
中科院分区：
文献类型：
--
作者：
Lecuit, Marc
人类李斯特菌病是一种由单核细胞增生李斯特菌引起的可能致命的食源性感染，这种李斯特菌是一种在环境中广泛存在的机会性嗜冷细菌。在工业化国家，由于出现了免疫功能低下的易感人群，以及大规模农业工业工厂和冷藏食品的相应发展，它最近才成为人类感染的一个重要原因。在此我们综述人类李斯特菌病的主要临床特征，并强调其与不同物种动物李斯特菌病的特异性和相似性。最后，我们介绍了选择合适的动物模型来研究人类李斯特菌病的一些关键决定因素。(C) 2007爱思唯尔马松公司。版权所有。
Human listeriosis is a potentially fatal foodbome infection caused by Listeria monocytogenes, an opportunistic psychrophile bacterium that is widespread in the environment. It has only recently emerged as a significant cause of human infection in industrialized countries, owing to appearance of a vulnerable population of immunocompromised individuals, and the concomitant development of large-scale agro-industrial plants and refrigerated food. Here we review the main clinical features of human listeriosis and highlight specificities and similarities with animal listeriosis in diverse species. Finally, we present some of the critical determinants for the choice of an appropriate animal model to study human listeriosis. (C) 2007 Elsevier Masson SAS. All rights reserved.