PATHOGENESIS OF LUPUS DERMATOSES IN AUTOIMMUNE MICE .12. EFFECTS OF ULTRAVIOLET-LIGHT IRRADIATION ON THE SKIN OF MRL-L MICE
PATHOGENESIS OF LUPUS DERMATOSES IN AUTOIMMUNE MICE .12. EFFECTS OF ULTRAVIOLET-LIGHT IRRADIATION ON THE SKIN OF MRL-L MICE
复制标题
DOI：
10.1007/bf00412595
复制
发表时间：
1987-01-01
影响因子：
3
通讯作者：
IMAMURA, S
中科院分区：
文献类型：
--
作者：
HORIGUCHI, Y;FURUKAWA, F;IMAMURA, S
用中波长紫外线(UVB)照射MRL/MP-LPR/LPR(MRL/I)和MRL/MP-+/+小鼠，观察皮损的发生、皮肤狼疮带试验(LBT)、血清中抗DNA抗体及肾小球肾炎的程度。长期暴露于低剂量UVB照射加速了MRL/I小鼠皮肤损伤的发展，并增强了阳性皮肤狼疮带的强度。UVB照射对血清中抗DNA抗体含量、LBT阳性发现率及肾小球肾炎程度均无影响。紫外线照射促进MRL/I小鼠皮损的发生与加速全身自身免疫现象无关。
MRL/Mp-lpr/lpr (MRL/I) and MRL/Mp-+/+ mice were irradiated with middle-wavelength ultraviolet light (UVB), and the development of skin lesions, skin lupus band test (LBT), anti-DNA antibodies in sera, and the extent of glomerulonephritis of the kidney were examined. Long-term exposure to low doses of UVB irradiation accelerated the development of skin lesions and enhanced the intensity of the positive skin lupus band in MRL/I mice. The contents of anti-DNA antibodies in sera, the incidence of positive findings in LBT, and the extent of glomerulonephritis were not influenced by the UVB irradiation. The promotion of the development of the skin lesions in MRL/I mice by the UVB exposure was not considered to be associated with acceleration of systemic autoimmune phenomena.