HYBRIDOMA FUSION CELL-LINES CONTAIN AN ABERRANT KAPPA TRANSCRIPT
HYBRIDOMA FUSION CELL-LINES CONTAIN AN ABERRANT KAPPA TRANSCRIPT
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DOI：
10.1016/0161-5890(88)90005-3
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发表时间：
1988-10-01
影响因子：
3.6
通讯作者：
LEVY, S
中科院分区：
文献类型：
--
作者：
CARROLL, WL;MENDEL, E;LEVY, S
已经确定了来自两个骨髓瘤融合伴侣的非生产性κ转录物的V区序列。该转录物具有异常的VJ重组位点，导致在位置105处的翻译终止位点。它在由来源于原始MOPC-21肿瘤的所有融合伴侣制备的杂交瘤中表达。该转录物的量可大大超过生产性轻链mRNA的水平。
The V region sequence of a non-productive kappa transcript from two myeloma fusion partners has been determined. This transcript has an aberrant VJ recombination site resulting in a translation stop site at position 105. It is variably expressed in hybridomas made from all fusion partners derived from the original MOPC-21 tumor. The amount of this transcript may greatly exceed levels of the productive light chain mRNA.