Human papillomaviruses: shared and distinct pathways for pathogenesis
Human papillomaviruses: shared and distinct pathways for pathogenesis
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DOI：
10.1016/j.coviro.2015.09.001
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发表时间：
2015-10-01
影响因子：
5.9
通讯作者：
Laimins, Laimonis A.
中科院分区：
文献类型：
--
作者：
Galloway, Denise A.;Laimins, Laimonis A.
超过200种类型的人乳头瘤病毒（HPV）已被确定感染不同解剖位置的上皮细胞。人乳头状瘤病毒分为五属，其中α和β病毒是最常被研究的。α HPV属的成员感染生殖器上皮，是许多肛门生殖器癌症的病原体。hpv感染皮肤上皮，并被认为是非黑色素瘤皮肤癌发展的辅助因素。最近的研究表明，DNA损伤途径的激活对α hpv的生产生命周期很重要，而β病毒则抑制其激活。这些差异可能导致与这些病毒相关的不同类型的病变和恶性肿瘤。
Over 200 types of human papillomaviruses (HPV) have been identified that infect epithelial cells at different anatomic locations. HPVs are grouped into five genera with the alpha and beta viruses being the most commonly studied. Members of the alpha HPV genus infect genital epithelia and are the causative agents of many anogenital cancers. Beta HPVs infect cutaneous epithelia and have been suggested as co-factors in the development of non-melanoma skin cancers. Recent studies have shown that activation of DNA damage pathways is important for the productive life cycle of the alpha HPVs while the beta viruses suppress their activation. These differences likely contribute to the varying types of lesions and malignancies that are associated with these viruses.