Evidence of extrinsic factors dominating intrinsic blood host preferences of major African malaria vectors.
Evidence of extrinsic factors dominating intrinsic blood host preferences of major African malaria vectors.
复制标题
外在因素主导非洲主要疟疾病媒内在血液宿主偏好的证据。
DOI：
10.1038/s41598-020-57732-1
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发表时间：
2020
影响因子：
4.6
通讯作者：
Orsborne J
中科院分区：
文献类型：
--
作者：
Orsborne J
决定吸血病媒传播病原体能力的一个关键因素是它选择从哪一个宿主那里获取血粉。这种选择受到内在（遗传）和外在（环境）因素的影响，但很少有人知道他们的相对贡献。从加纳一个疟疾流行的村庄收集了吸血按蚊。收集是在一系列不同的主机可用性和室内和室外位置进行的。这些环境因素被证明会极大地影响被捕获的疟疾病媒的宿主选择：在室内捕获的蚊子从人类那里获得血餐的可能性是在室内捕获的蚊子的10倍;在距离村庄中心仅25米的地方捕获的蚊子被人类喂养的可能性减半。对于第一次，我们证明，食虫性是更好地解释外在因素（即，本地主机的可用性和室内/室外诱捕位置）比内在因素（即，（兄弟姐妹）种捕获的蚊子）（各自赤池信息标准估计：243.0与359.8）。而不是咬行为的分类水平上的特点，我们说明了评估当地昆虫学的重要性。考虑到这种行为的可塑性是重要的，无论是在衡量控制方案的有效性，并在通知最佳的疾病控制策略。
One of the key determinants of a haematophagous vector’s capacity to transmit pathogens is its selection of which host to secure a blood meal from. This choice is influenced by both intrinsic (genetic) and extrinsic (environmental) factors, but little is known of their relative contributions. Blood fedAnophelesmosquitoes were collected from a malaria endemic village in Ghana. Collections were conducted across a range of different host availabilities and from both indoor and outdoor locations. These environmental factors were shown to impact dramatically the host choice of caught malaria vectors: mosquitoes caught indoors were ten-fold more likely to have sourced their blood meal from humans; and a halving in odds of being human-fed was found for mosquitoes caught only 25 m from the centre of the village. For the first time, we demonstrate that anthropophagy was better explained by extrinsic factors (namely, local host availability and indoor/outdoor trapping location) than intrinsic factors (namely, the (sibling) species of the mosquito caught) (respective Akaike information criterion estimates: 243.0 versus 359.8). Instead of characterizing biting behaviour on a taxonomic level, we illustrate the importance of assessing local entomology. Accounting for this behavioural plasticity is important, both in terms of measuring effectiveness of control programmes and in informing optimal disease control strategies.