Delivering baking soda to the brain.
Delivering baking soda to the brain.
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将小苏打输送到大脑。
DOI：
10.1113/jp277119
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Bevensee,MarkO
中科院分区：
文献类型：
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作者：
Bevensee,MarkO
维持生物体的酸碱状态需要通过以下三个主要系统来协调调节血浆pH：HCO3−和非HCO3−物种的H+缓冲，肾脏机制的HCO3−重吸收/H+排泄，以及肺通气机调节PCO2。大脑中的中枢化学感受器通过感知二氧化碳/H+的变化而参与呼吸反应。因此，体循环必须通过血-脑脊液和血脑屏障将其二氧化碳/酸碱状态传递到脑脊液(CSF)和脑间质液。最优的pH调节需要二氧化碳和远远不那么刻意的酸碱物种(如HCO3−)的平衡移动跨越这些障碍。哪些关键蛋白质负责这种HCO3−的移动？在最近一期的《华尔街日报》上
The proper maintenance of organismal acid–base status requires the choreographed regulation of plasma pH by the following three major systems: H+ buffering by HCO3− and non-HCO3− species, HCO3− reabsorption/H+ excretion by renal mechanisms, and PCO2 adjustments by pulmonary ventilation. Central chemoreceptors in the brain contribute to the ventilatory response by sensing changes in CO2/H+. The systemic circulation must therefore relay its PCO2/acid–base status to the cerebrospinal fluid (CSF) and brain interstitial fluid via the blood–CSF and blood–brain barriers. Optimal pH regulation requires balanced movement of both CO2 and far less permeant acid–base species such as HCO3− across these barriers. What key proteins are responsible for such HCO3− movement? In a recent issue of The Journal of