Biofabrication for osteochondral tissue regeneration: bioink printability requirements
Biofabrication for osteochondral tissue regeneration: bioink printability requirements
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DOI：
10.1007/s10856-019-6218-x
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发表时间：
2019-02-01
影响因子：
3.7
通讯作者：
Morouco, Pedro G.
中科院分区：
文献类型：
--
作者：
Abdulghani, Saba;Morouco, Pedro G.
生物制造允许通过精确的空间控制来形成3D支架。当以模仿异质和各向异性结构为目标时，这是最重要的，例如骨软骨组织的结构。由于层状结构的成分和结构的复杂性，以及软骨-骨界面的生物力学特性的反差，骨软骨缺损是组织工程面临的最大挑战。本文以骨软骨组织为例，重点介绍了利用已开发的生物墨水进行组织再生的研究进展和研究进展。讨论了生物打印的方法、材料和要求，强调了研究人员在开发临床治疗时应考虑的前后处理因素。
Biofabrication allows the formation of 3D scaffolds through a precise spatial control. This is of foremost importance when aiming to mimic heterogeneous and anisotropic architecture, such as that of the osteochondral tissue. Osteochondral defects are a supreme challenge for tissue engineering due to the compositional and structural complexity of stratified architecture and contrasting biomechanical properties of the cartilage-bone interface. This review highlights the advancements and retreats witnessed by using developed bioinks for tissue regeneration, taking osteochondral tissue as a challenging example. Methods, materials and requirements for bioprinting were discussed, highlighting the pre and post-processing factors that researchers should consider towards the development of a clinical treatment.