Midbrain Transcranial Sonography in Korean patients with Parkinson's disease
Midbrain Transcranial Sonography in Korean patients with Parkinson's disease
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DOI：
10.1002/mds.21628
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发表时间：
2007-10-15
影响因子：
8.6
通讯作者：
Lee, Won Yong
中科院分区：
文献类型：
--
作者：
Kim, Ji Youn;Kim, Seong Tae;Lee, Won Yong
经颅超声（TCS）对帕金森病（PD）的诊断有潜在的价值。然而，关于TCS的研究迄今仅限于欧洲人群。为探讨TCS对韩国PD患者的疗效及其与临床特征的相关性，我们对43例PD患者和35例正常对照者进行了中脑TCS，并评估了黑质（SN）强回声区的面积及其占整个中脑面积的比例。在16名受试者（21%）中，由于颞骨声窗不足，TCS未成功。PD组双侧黑质强回声区平均面积及其与中脑面积的比值均大于对照组（P < 0.01）。PD患者SN强回声区面积及其占中脑面积的比例与PD病程呈中度相关（r分别为0.526和0.536，P = 0.01），而与年龄、H-Y分期、H-RS运动评分无相关性。震颤型、运动不能型和混合型PD患者的SN高回声性无差异。总之，中脑TCS是一种有效的诊断工具，检测PD在韩国人口。然而，它不能反映帕金森综合征的严重程度或表型。(C)2007年，《社会运动》创刊。
Transcranial sonography (TCS) is potentially useful for the diagnosis of Parkinson's disease (PD). However, studies on TCS have so far been restricted to European populations. To investigate the efficacy of TCS in Korean PD patients and its correlation with the clinical features, we carried out midbrain TCS in 43 PD patients and 35 normal controls and evaluated the area of the substantia nigra (SN) hyperechogenicity and its ratio to the area of the whole midbrain. In 16 subjects (21%), TCS was unsuccessful due to insufficient acoustic temporal bone windows. The mean area of bilateral SN hyperechogenicity and its ratio to the midbrain area were greater in the PD patients than that in the controls (P < 0.01). In the PD patients, the area of SN hyperechogenicity and its ratio to the individual midbrain area were moderately correlated with the PD, duration (r = 0.526 and 0.536, P = 0.01, respectively) but not with the age, UPDRS motor scores or H-Y stage. There was no difference in the SN hyperechogenicity between the tremor-dominant, akinetic-rigid, and mixed-type PD patients. In conclusion, midbrain TCS is an effective diagnostic tool for detecting PD in the Korean population. However, it does not reflect the severity or phenotypes of parkinsonism. (C) 2007 Movement Disorder Society.