Polyamine transport and metabolism in mouse mammary gland. General properties and hormonal regulation.
Polyamine transport and metabolism in mouse mammary gland. General properties and hormonal regulation.
复制标题
小鼠乳腺中的多胺转运和代谢。
DOI：
10.1016/s0021-9258(17)33558-5
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发表时间：
1976
期刊：
影响因子：
--
通讯作者：
T. Oka
中科院分区：
文献类型：
--
作者：
K. Kano;T. Oka
小鼠乳腺已被证明具有亚精胺、精胺和腐胺的运输系统。正如在培养的乳腺外植体上详细研究的那样，亚精胺的吸收系统是一个时间依赖性、需要能量的过程，可以通过胰岛素和催乳素刺激。胰岛素的刺激作用涉及增强亚精胺流入的Vmax和防止多胺流出，而催乳素在胰岛素存在下引起亚精胺的Vmax更大增加。还报道了温度、浓度和各种抑制剂对该系统影响的研究。积累的亚精胺实际上以未改变的形式存在，几乎没有代谢转化为精胺或腐胺或其结合形式。相比之下，精胺和腐胺也被乳腺外植体吸收，并代谢转化为亚精胺。
Mouse mammary gland has been shown to possess a transport system for spermidine, spermine, and putrescine. The uptake system for sperimidine, as studied in detail on mammary explants in culture is a time-dependent, energy-requiring process which can be stimulated by insulin and prolactin. The stimulatory effect of insulin involves both enhancement of Vmax for spermidine influx and prevention of efflux of the polyamine, whereas prolactin, in the presence of insulin, elicits a greater increase in Vmax for spermidine. Studies are also reported on the effects of temperature, concentration, and various inhibitors on this system. The accumulated spermidine exists virtually in an unchanged form with little metabolic conversion to either spermine or putrescine or to its conjugated form. In contrast, spermine and putrescine, both of which are also taken up by mammary explants, undergo metabolic conversion to spermidine.