Experimental botulism in Pekin ducks.
Experimental botulism in Pekin ducks.
复制标题
北京鸭实验性肉毒杆菌中毒。
DOI：
10.2307/1589803
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发表时间：
1980
期刊：
影响因子：
1.4
通讯作者：
S. Kozaki
中科院分区：
文献类型：
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作者：
S. Notermans;J. Dufrenne;S. Kozaki
B型、C型和E型肉毒杆菌孢子经口服给活北京鸭后，在被杀北京鸭中发现产生毒素。在施用孢子后40分钟内杀死鸭子时，发现毒素产量最高。如果在4小时后宰杀，则只发现少量毒素或根本没有毒素。北京鸭经口给药后对C-L型肉毒毒素敏感，LD50为9.6 × 10(4)小鼠腹腔内LD50。B-L、B-M、C-M和E型毒素未能产生肉毒中毒症状。B-L型、B-M型、C-L型、E型小鼠静脉LD50分别为1.5 × 10(4)、1.6 × 10(4)、3.0 × 10(2)、2.5 × 10(6)。虽然结果明确表明鸭对B型和E型肉毒杆菌毒素不敏感，但B型和E型肉毒杆菌在死鸭体内繁殖和产生毒素是可能的。因此，这些尸体可能是环境中这些类型循环的媒介。
Clostridium botulinum types B, C, and E were found to produce toxin in killed Pekin ducks after oral administration of spores to the live birds. The highest toxin production was found when the ducks were killed within 40 minutes after the administration of the spores. If the ducks were killed after 4 hours, only small amounts of toxin or no toxin at all was found. Pekin ducks were sensitive to botulinum toxin type C-L after oral administration, the LD50 being 9.6 X 10(4) intraperitoneal mouse LD50. Toxin types B-L, B-M, C-M, and E failed to produce symptoms of botulism. The intravenous LD50 for types B-L, B-M, C-L, and E were respectively 1.5 X 10(4), 1.6 X 10(4), 3.0 X 10(2), and 2.5 X 10(6) intraperitoneal mouse LD50. Although the results clearly showed that ducks are orally not sensitive for botulinum toxin types B and E, multiplication and toxin production of C. botulinum types B and E in dead ducks is possible. Therefore, such carcasses can be vectors in cycles of these types in the environment.