Activity of minocycline against Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae clinical isolates, with comparison to doxycycline and tigecycline
Activity of minocycline against Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae clinical isolates, with comparison to doxycycline and tigecycline
复制标题
DOI：
10.1016/j.diagmicrobio.2017.05.004
复制
发表时间：
2017-08-01
影响因子：
2.9
通讯作者：
Hirsch, Elizabeth B.
中科院分区：
文献类型：
--
作者：
Chen, Alice;Smith, Kenneth P.;Hirsch, Elizabeth B.
我们检测了米诺环素对103株产肺炎克雷伯菌碳青霉烯酶（KPC）的肠杆菌科分离株的体外活性，发现大约一半的菌株具有敏感（26%）或中间（26%）mic。对于35个分离株的亚群，对替加环素的敏感性最高（71% FDA vs 20% EUCAST），其次是米诺环素（14%），然后是强力霉素（6%）。(C) 2017爱思唯尔公司版权所有。
We examined the in vitro activity of minocycline against 103 Klebsiella pneumoniae carbapenemase (KPC)producing Enterobacteriaceae isolates and found approximately half had susceptible (26%) or intermediate (26%) MICs. For a subset of 35 isolates, susceptibility was highest to tigecycline (71% FDA vs. 20% EUCAST) followed by minocycline (14%) and then doxycycline (6%). (C) 2017 Elsevier Inc. All rights reserved.