The emerging role of the ubiquitin proteasome in pulmonary biology and disease.
The emerging role of the ubiquitin proteasome in pulmonary biology and disease.
复制标题
泛素蛋白酶体在肺部生物学和疾病中的新作用。
DOI：
10.1164/rccm.201304-0754pp
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发表时间：
2013
影响因子：
24.7
通讯作者：
Mallampalli,RamaK
中科院分区：
文献类型：
--
作者：
Weathington,NathanielM;Sznajder,JacobI;Mallampalli,RamaK
正常细胞内稳态在蛋白质水平上的紊乱可引起或成为与基因型、感染、损伤、吸烟、毒素暴露或肿瘤相关的肺部疾病的发生和进展的结果。我们讨论了蛋白质稳态的基本机制之一，泛素蛋白酶体系统（UPS），因为它与肺部疾病有关。UPS通过泛素连接酶活性影响泛素化靶蛋白的选择性降解。与UPS和肺部疾病相关的重要病理生物学机制一直是研究的重点，不适当的细胞蛋白水解现在是一个经过验证的治疗靶点。我们回顾了该系统在各种肺部疾病中的贡献，并讨论了针对肺部疾病的ups靶向药物开发的令人兴奋的领域。
Derangements in normal cellular homeostasis at the protein level can cause or be the consequence of initiation and progression of pulmonary diseases related to genotype, infection, injury, smoking, toxin exposure, or neoplasm. We discuss one of the fundamental mechanisms of protein homeostasis, the ubiquitin proteasome system (UPS), as it relates to lung disease. The UPS effects selective degradation of ubiquitinated target proteins via ubiquitin ligase activity. Important pathobiological mechanisms relating to the UPS and lung disease have been the focus of research, with inappropriate cellular proteolysis now a validated therapeutic target. We review the contributions of this system in various lung diseases, and discuss the exciting area of UPS-targeting drug development for pulmonary disease.