The contributions of resistin and adiponectin gene single nucleotide polymorphisms to the genetic risk for polycystic ovary syndrome in a Japanese population
The contributions of resistin and adiponectin gene single nucleotide polymorphisms to the genetic risk for polycystic ovary syndrome in a Japanese population
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DOI：
10.1080/09513590902972042
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发表时间：
2009-01-01
影响因子：
2
通讯作者：
Saito, Tsuyoshi
中科院分区：
文献类型：
--
作者：
Baba, Tsuyoshi;Endo, Toshiaki;Saito, Tsuyoshi
多囊卵巢综合征（PCOS）是一种异质性疾病，常见于育龄妇女，具有多种临床表现，包括独立于肥胖的胰岛素抵抗。最近的研究表明，脂肪细胞因子基因表达的改变与胰岛素抵抗密切相关，单核苷酸多态性（snp）调节这些基因的表达和/或功能，从而影响胰岛素敏感性。考虑到这一点，我们研究了抵抗素基因（RETN） 7420位和/或脂联素基因（ADIPOQ） 711377位的snp是否调节PCOS的易感性。我们评估了117名多囊卵巢综合征女性和380名健康生育对照者的基因型，并测量了多囊卵巢综合征女性的胰岛素抵抗指数和激素谱。RETN 7420G/G纯合变异基因型在PCOS组中的发生率明显高于对照组（15.4%比8.4%,p = 0.035）。RETN 7420G/ G基因型的PCOS女性也比RETN 7420c /C或C/G基因型的PCOS女性表现出更高的bmi和更大的胰岛素抵抗。位于711377的ADIPOQ SNP与PCOS无关联。我们的结论是，7420基因型的RETN G/G与日本女性的PCOS有关。
Polycystic ovary syndrome (PCOS) is a heterogeneous group of disorders that occur fairly commonly in women of reproductive age and are characterized by a variety of clinical manifestations, including insulin resistance that is independent of obesity. Recent studies suggest that altered adipocytokine gene expression is closely associated with insulin resistance and that single nucleotide polymorphisms (SNPs) modulate the expression and/or function of these genes, thereby affecting insulin sensitivity. With that in mind, we investigated whether SNPs at position 7420 of the resistin gene (RETN) and/or 711377 of the adiponectin gene (ADIPOQ) modulate the susceptibility to PCOS. We evaluated the genotypes of 117 women with PCOS and 380 healthy fertile controls and measured the index of insulin resistance and hormonal profiles in the PCOS women. The RETN 7420G/G homozygous variant genotype occurred significantly more frequently among the PCOS group than among the control group (15.4% vs. 8.4%, p = 0.035). PCOS women with the RETN 7420G/ G genotype also showed significantly higher BMIs and greater insulin resistance than those with RETN 7420 C/C or C/G genotypes. The ADIPOQ SNP at 711377 showed no association with PCOS. We conclude that the RETN G/G at 7420 genotype is associated with PCOS in Japanese women.