CTHRC1 May Serve As A Prognostic Biomarker For Hepatocellular Carcinoma
CTHRC1 May Serve As A Prognostic Biomarker For Hepatocellular Carcinoma
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CTHRC1 可能作为肝细胞癌的预后生物标志物
DOI：
10.2147/ott.s219429
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发表时间：
2019-01-01
影响因子：
4
通讯作者：
Sun, Dianxing
中科院分区：
文献类型：
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作者：
Zhou, Huifang;Su, Libo;Sun, Dianxing
背景：肝细胞癌是一种常见的恶性肿瘤，也是全球癌症相关死亡的第二大常见原因。越来越多的报道称胶原蛋白三螺旋重复序列 1 (CTHRC1) 参与肿瘤发生和/或肿瘤进展。然而，关于CTHRC1在肝细胞癌中的作用的可用数据有限。方法：我们的研究中收集了来自总共29名HCC患者的石蜡包埋标本。使用免疫组织化学和生物信息学分析评估肝细胞癌中CTHRC1的表达。此外，进行 Spearman 分析以确定 CTHRC1 与临床病理特征之间的相关因素。使用Kaplan-Meier法和对数秩检验绘制肝细胞癌的生存曲线。结果：在本研究中，我们证实CTHRC1在组织和肝癌细胞系中高表达。统计分析显示，CTHRC1水平与肝硬化(P=0.024)、肿瘤大小(P=0.006)、血管侵犯(P
Background: Hepatocellular carcinoma is a common malignant cancer and the second most common cause of cancer-related deaths worldwide. Collagen triple helix repeat containing 1 (CTHRC1) has been increasingly reported to be involved in tumorigenesis and/or tumor progression. However, limited data are available regarding the role of CTHRC1 in hepatocellular carcinoma.Methods: Paraffin-embedded specimens from a total of 29 patients with HCC were collected in our study. The expression of CTHRC1 in hepatocellular carcinoma was evaluated using immunohistochemistry and bioinformatics analysis. Furthermore, Spearman analysis was performed to identify factors of correlation between CTHRC1 and clinicopathological features. Survival curves for hepatocellular carcinoma were produced using the Kaplan-Meier method and the log rank test.Results: In this study, we confirmed that CTHRC1 is highly expressed in tissues and hepatoma cell lines. The statistical analysis revealed that the levels of CTHRC1 were significantly correlated with cirrhosis (P=0.024), tumor size (P=0.006), vascular invasion (P