Cytokines and Biologics in non-infectious autoimmune uveitis: bench to bedside.
Cytokines and Biologics in non-infectious autoimmune uveitis: bench to bedside.
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DOI：
10.4103/0301-4738.126187
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发表时间：
2014-01
影响因子：
3.1
通讯作者：
Teoh S
中科院分区：
文献类型：
--
作者：
Agrawal R;Iyer J;Connolly J;Iwata D;Teoh S
眼内炎症性眼病是眼部疾病的重要原因之一。尽管与糖尿病视网膜病变、青光眼或老年性黄斑变性相关的葡萄膜炎发病率较低，但这种疾病的复杂性和异质性使其更具独特性。大量实验研究表明，葡萄膜原性视网膜抗原通过抗原模拟过程激发天然免疫，并与眼内炎症性疾病相关。在过去的二十年里，帮助眼内炎性疾病病因学关联的实验室诊断工具得到了发展，我们正在进入一个分子诊断测试的时代。先进的新技术，如用于评估生物特征的多重珠粒分析，已经彻底改变了复杂的难治性葡萄膜炎的治疗方法。然而，要建立这些生物标志物和特定葡萄膜实体之间的因果关系，还有很长的路要走。实验研究表明英夫利昔单抗在治疗白塞病中的最高作用。尽管有重要的实验和病例对照研究，但使用这些生物制剂的随机临床试验的缺乏阻碍了我们探索它们作为严重难治性葡萄膜炎的一线治疗方法。研究仍然需要回答这些潜在威胁生命的药物在选定的一组患者中的安全性，并确定何时开始治疗以及必须给予多久的治疗。本文综述了细胞因子在葡萄膜炎中的一些基本概念及其在难治性葡萄膜炎治疗中的潜在应用。
Intraocular inflammatory eye disease is one of the important causes of ocular morbidity. Even though the prevalence of uveitis is less common in relation to diabetic retinopathy, glaucoma or age related macular degeneration, the complexity and heterogeneity of the disease makes it more unique. Putative uveitogenic retinal antigens incite innate immunity by the process of antigen mimicry and have been shown to be associated in patients with intraocular inflammatory disease by numerous experimental studies. Laboratory diagnostic tools to aid the etiologic association in intraocular inflammatory disease have evolved over the last two decades and we are entering into an era of molecular diagnostic tests. Sophisticated novel technologies such as multiplex bead assays to assess biological signatures have revolutionized the management of complex refractory uveitis. Nevertheless, there is still a long way to go to establish the causal relationship between these biomarkers and specific uveitic entities. Experimental studies have shown the supreme role of infliximab in the management of Behcet's disease. Despite significant experimental and case control studies, the deficiency of randomized clinical trials using these biologic agents has handicapped us in exploring them as a front line therapy in severe refractory uveitis. Studies still need to answer the safety of these potentially life threatening drugs in a selected group of patients and determine when to commence and for how long the treatment has to be given. This review article covers some basic concepts of cytokines in uveitis and their potential application for therapy in refractory uveitis.
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影响因子：
4.1
作者：
DICK, AD
通讯作者：
DICK, AD
影响因子：
3.5
作者：
Lane, Jerome;McLaren, Paul J.;Fellay, Jacques
通讯作者：
Fellay, Jacques
影响因子：
--
作者：
De Rycke, L;Baeten, D;De Keyser, F
通讯作者：
De Keyser, F
影响因子：
4.4
作者：
Curnow, SJ;Falciani, F;Murray, PI
通讯作者：
Murray, PI
影响因子：
4.4
作者：
Atan, Denize;Fraser-Bell, Samantha;Churchill, Amanda J.
通讯作者：
Churchill, Amanda J.