Use of enhanced computerized tomography to evaluate osmotic blood-brain barrier disruption
Use of enhanced computerized tomography to evaluate osmotic blood-brain barrier disruption
复制标题
使用增强计算机断层扫描评估渗透性血脑屏障破坏
DOI：
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发表时间：
1980
期刊：
影响因子：
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通讯作者：
R. Moore
中科院分区：
文献类型：
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作者：
E. Neuwelt;K. Maravilla;E. Frenkel;P. Barnett;S. Hill;R. Moore
增强型计算机断层扫描 (CT) 是一种监测血脑屏障 (BBB) 破坏的无创方法。在本研究中，该技术用于监测渗透性血脑屏障破坏的程度、分布、范围和可逆性。在犬模型中，碘造影剂的给药时机被证明对于优化 CT 增强破坏的血脑屏障至关重要。静脉注射碘酞酸葡胺可在 CT 扫描上产生出色的增强效果。这种造影剂的颈动脉内输注不太令人满意。在相似的条件下，与用碘酞酸葡甲胺观察到的增强相比，甲曲酰胺引起的增强不太明显且更短暂。渗透性血脑屏障破坏后全身施用甲氨蝶呤导致与 CT 扫描增强密切相关的区域的脑水平升高。这些结果表明，CT 扫描为 BBB 破坏和化疗药物向大脑的输送提供了良好的无创监测。 （神经外科 6：49--56，1980）
Enhanced computerized tomography (CT) is a noninvasive means of monitoring blood-brain barrier (BBB) disruption. In the present study this technique was used to monitor the degree, distribution, extent, and reversibility of osmotic BBB disruption. With a canine model, the timing of administration of iodinated contrast agent was shown to be crucial to optimize enhancement by CT of the disrupted BBB. Meglumine iothalamate given intravenously resulted in excellent enhancement on CT scan. Intracarotid infusion of this contrast agent was less satisfactory. Under similar conditions, enhancement due to metrizamide was less marked and more transient than that observed with meglumine iothalamate. Systemically administered methotrexate after osmotic BBB disruption resulted in increased brain levels in areas that closely correlated with CT scan enhancement. These results suggest that the CT scan provides an excellent noninvasive monitor of both BBB disruption and the delivery of chemotherapeutic agents to the brain. (Neurosurgery 6: 49--56, 1980)