EPIDEMIOLOGY OF EPILEPSY IN GUAYMI INDIANS FROM BOCAS-DEL-TORO PROVINCE, REPUBLIC OF PANAMA
EPIDEMIOLOGY OF EPILEPSY IN GUAYMI INDIANS FROM BOCAS-DEL-TORO PROVINCE, REPUBLIC OF PANAMA
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DOI：
10.1111/j.1528-1157.1990.tb05512.x
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发表时间：
1990-11-01
期刊：
影响因子：
5.6
通讯作者：
REEVES, WC
中科院分区：
文献类型：
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作者：
GRACIA, F;DELAO, SL;REEVES, WC
这项横断面研究是为了描述居住在Changuinola的Guaymi印第安人癫痫的流行病学，Changuinola是巴拿马加勒比海沿岸靠近哥斯达黎加的一个小镇。我们随机选择住户，并试图招募所有年龄在10岁以下的居民。1年; 337例合格受试者同意参加（93%的应答率）。我们对所有受试者进行了标准的神经系统疾病筛查检查，如果发现任何异常，我们进行了标准的神经系统评估。我们检测到19例活动性癫痫，发病时的平均年龄为12岁，全身强直阵挛性癫痫发作是最常见的诊断（10 19，53%）。加勒比海沿岸瓜伊米人活动性癫痫的患病率（57/1000）远高于低层巴拿马城人口（22/1000）或世界其他地区。为了确定癫痫的危险因素，我们收集了活动性癫痫患者和44名年龄/性别匹配的对照组的流行病学数据和血清（囊尾蚴抗体）。与对照组（6%）相比，显著更多的病例（47%）有其他癫痫家族成员（相对风险，RR = 14）; 44%的病例和13%的对照组报告了儿童期热性惊厥史（RR =6）。
This cross-sectional study was conducted to describe the epidemiology of epilepsy in Guaymi Indians residing in Changuinola, a small town on Panama''s Caribbean coast near Costa Rica. We randomly selected households and attempted to enroll all residents aged .ltoreq. 1 year; 337 eligible subjects agreed to participate (93% response rate). We administered a standard neurologic disease screening examination to all subjects and, if any abnormality was found, we administered a standard neurologic evaluation. We detected 19 cases of active epilepsy; the mean age at onset was 12 years, and generalized tonic-clonic seizures were the most common diagnosis (10 of 19, 53%). The prevalence of active epilepsy among Caribbean coastal Guaymi (57/1000) is considerably greater than that in lower class Panama City populations (22/1000) or in other parts of the world. To identify risk factors for epilepsy, we collected epidemiologic data and serum (for Cysticercus antibody) from subjects with active epilepsy and from 44 age/sex-matched controls. Significantly more cases (47%) than controls (6%) had other family members with epilepsy (relative risk, RR = 14); 44% of cases and 13% of controls reported a history of febrile seizures during childhood (RR =6).