Constitutional, biochemical and lifestyle correlates of fibrinogen and factor VII activity in Polish urban and rural populations.
Constitutional, biochemical and lifestyle correlates of fibrinogen and factor VII activity in Polish urban and rural populations.
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波兰城市和农村人口的体质、生化和生活方式与纤维蛋白原和凝血因子 VII 活性相关。
DOI：
10.1093/ije/27.6.953
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发表时间：
1998
影响因子：
7.7
通讯作者：
Thomas,RP
中科院分区：
文献类型：
--
作者：
Pajak,A;Broda,G;Manolio,TA;Kawalec,E;Rywik,S;Davis,CE;Pikon,J;Pytlak,A;Thomas,RP
背景纤维蛋白原和因子VII活性与动脉粥样硬化和冠心病有关，方法对2443名35岁以下的男性和女性的血浆纤维蛋白原浓度和因子VII活性进行相关性研究，从华沙市区两个区的居民中随机抽取64份样本，（618名男子和651名妇女）和塔尔诺布热格省农村人口（556名男性和618名女性）在1987-1988年进行筛查，并评估哪些特征可能解释城乡差异。纤维蛋白原和因子VII活性测定使用凝血methods.ResultsFibrinogen是12.9毫克/分升，男性和14.1毫克/分升，女性在塔尔诺布热格华沙相比。华沙的凝血因子VII活性较高（男性为9.2%，女性为15.3%）。调整选定的特征后，吸烟者的纤维蛋白原高于非吸烟者，男性为28 mg/dl，女性为22 mg/dl。在女性中，HDL-胆固醇升高15 mg/dl与纤维蛋白原降低10 mg/dl相关（P< 0.01）。在调整其他变量后，华沙的VII因子活性较高（男性差异为9.4%，女性差异为14.8%）。较低的纤维蛋白原在华沙仍然显着，只有在妇女（15.4毫克/天/升的差异）。ConclusionsThe研究证实，性别，年龄，体重指数，吸烟和血脂与打点因素。然而，除性别差异和吸烟外，凝血因子与其他变量之间的关联很小，实际重要性值得怀疑。
BackgroundFibrinogen and factor VII activity are known to be related to atherosclerosis and coronary heart disease, but population differences in dotting factors and modifiable characteristics that influence their levels have not been widely explored.MethodsThis paper examines correlates of plasma fibrinogen concentration and factor VII activity in 2443 men and women aged 35–64 in random samples selected from the residents in two districts in urban Warsaw (618 men and 651 women) and from rural Tarnobrzeg Province (556 men and 618 women) screened in 1987–1988, and assesses which characteristics might explain urban-rural differences. Fibririogen and factor VII activity were determined using coagulation methods.ResultsFibrinogen was 12.9 mg/dl higher in men and 14.1 mg/dl higher in women in Tarnobrzeg compared to Warsaw. Factor VII activity was higher in Warsaw (9.2% in men and 15.3% in women). After adjustment for selected characteristics, fibrinogen was higher in smokers compared to non-smokers by 28 mg/dl in men and 22 mg/dl in women. In women, a 15 mg/dl increase in HDL-cholesterol was associated with a 10 mg/dl decrease in fibrinogen (P< 0.01). After adjustment for other variables, a higher factor VII activity in Warsaw remained significant (a difference of 9.4% in men and 14.8% in women). Lower fibrinogen in Warsaw remained significant only in women (15.4 mg/d/l difference).ConclusionsThe study confirmed that sex, age, BMI, smoking and blood lipids are related to dotting factors. However, with the exception of gender differences and smoking, associations between clotting factors and other variables were small and of questionable practical importance.
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