Relation between insulin-like growth factor-1 receptor and human papilloma virus in patients with oropharyngeal cancer
Relation between insulin-like growth factor-1 receptor and human papilloma virus in patients with oropharyngeal cancer
复制标题
口咽癌患者胰岛素样生长因子1受体与人乳头瘤病毒的关系
DOI：
10.1002/hed.23702
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
K Ikeda.
中科院分区：
文献类型：
--
作者：
F Matsumoto;M Fujimaki;S Ohba;M Kojima;J Yokoyama;K Ikeda.
人类乳头状瘤病毒（HPV）阳性的口咽鳞状细胞癌（SCC）比HPV阴性的口咽鳞状细胞癌（SCC）预后更好。本研究的目的是评估胰岛素样生长因子-1受体（IGF-1 R）在口咽鳞癌患者的表达，其关系到HPV的状态和各种临床参数，其与临床outcome.MethodsThe研究对象是59例口咽鳞癌患者。通过免疫组织化学检测石蜡包埋肿瘤组织中的IGF-1 R表达。结果IGF-1 R与临床参数无相关性，但IGF-1 R在HPV阴性肿瘤中的表达较HPV阳性肿瘤更为常见。IGF-1 R阳性组患者的预后差于IGF-1 R阴性组。结论口咽鳞癌中IGF-1 R的表达与HPV阴性患者的不良预后相关。针对IGF-1 R的治疗可能会改善HPV阴性口咽SCC患者的生存率。© 2014 Wiley Periodicals，Inc.头颈部37：977-981，2015
BackgroundHuman papillomavirus (HPV)‐positive oropharyngeal squamous cell carcinoma (SCC) is associated with better prognosis than HPV‐negative oropharyngeal SCC. The purpose of this study was to assess the expression of insulin‐like growth factor‐1 receptor (IGF‐1R) in patients with oropharyngeal SCC, its relationship to HPV status and various clinical parameters, and its relationship with clinical outcome.MethodsThe study subjects were 59 patients with oropharyngeal SCC. IGF‐1R expression was examined by immunohistochemistry in paraffin‐embedded tumor tissues. HPV status was evaluated by in situ hybridization (ISH) in the same tissues.ResultsIGF‐1R did not correlate with clinical parameters, but IGF‐1R expression was more common in HPV‐negative tumors than in HPV‐positive tumors. The prognosis was poorer in patients of the IGF‐1R‐positive group than in the IGF‐1R‐negative group.ConclusionThe results suggested that IGF‐1R expression in oropharyngeal SCC correlated with poor prognosis in HPV‐negative patients. Treatment targeting IGF‐1R could potentially improve the survival of patients with HPV‐negative oropharyngeal SCC. © 2014 Wiley Periodicals, Inc. Head Neck 37: 977–981, 2015