Individual-Level Identification of Gene Expression Associated with Volume Differences among Neocortical Areas
Individual-Level Identification of Gene Expression Associated with Volume Differences among Neocortical Areas
复制标题
与新皮质区域体积差异相关的基因表达的个体水平识别
DOI：
10.1093/cercor/bhz333
复制
发表时间：
2020-06-01
期刊：
影响因子：
3.7
通讯作者：
Yu, Chunshui
中科院分区：
文献类型：
--
作者：
Fu, Jilian;Liu, Feng;Yu, Chunshui
人类大脑皮层是许多复杂行为的来源，也是各种神经精神疾病的易受攻击的目标，但与大脑皮层体积（CCV）差异相关的转录谱仍然未知。在这里，我们使用跨样本空间相关性分析在6个死后大脑中筛选CCV相关基因，然后在1091个具有不同年龄和种族的受试者中单独验证这些相关性。我们确定了62个基因，其转录谱在超过90%的个体中与CCV重复相关。CCV相关基因在神经元和从童年中期到成年早期的发育期特异性表达，在离子通道和发育过程中富集，并与与脑功能活动和精神障碍相关的基因有显著重叠。这些基因代表了人类大脑皮层保守的转录结构，表明保守的基因转录和新皮层结构特性之间存在联系。
The human cerebral cortex is the source of many complex behaviors and is a vulnerable target of various neuropsychiatric disorders, but transcriptional profiles linked to cerebral cortical volume (CCV) differences across brain areas remain unknown. Here, we screened CCV-related genes using an across-sample spatial correlation analysis in 6 postmortem brains and then individually validated these correlations in 1091 subjects with different ages and ethnicities. We identified 62 genes whose transcriptional profiles were repeatedly associated with CCV in more than 90% of individuals. CCV-related genes were specifically expressed in neurons and in developmental periods from middle childhood to young adulthood, were enriched in ion channels and developmental processes, and showed significant overlap with genes linked to brain functional activity and mental disorders. The identified genes represent the conserved transcriptional architecture of the human cerebral cortex, suggesting a link between conserved gene transcription and neocortical structural properties.